ODC1, 1-461aa, Human, His tag, E Coli | MyBioSource MBS204706 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

ODC1, 1-461aa, Human, His tag, E Coli

catalog :

MBS204706

quantity :

0.05 mg

price :

375 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS204706

products type :

Recombinant Protein

products full name :

ODC1, 1-461aa, Human, His tag, E Coli

products short name :

ODC1

products name syn :

Ornithine decarboxylase; ODC

other names :

ornithine decarboxylase isoform 1; Ornithine decarboxylase; ornithine decarboxylase; ornithine decarboxylase 1

products gene name :

ODC1

other gene names :

ODC1; ODC1; ODC; ODC

uniprot entry name :

DCOR_HUMAN

sequence length :

461

sequence :

MGSSHHHHHH SSGLVPRGSH MGSMNNFGNE EFDCHFLDEG FTAKDILDQK INEVSSSDDK DAFYVADLGD ILKKHLRWLK ALPRVTPFYA VKCNDSKAIV KTLAATGTGF DCASKTEIQL VQSLGVPPER IIYANPCKQV SQIKYAANNG VQMMTFDSEV ELMKVARAHP KAKLVLRIAT DDSKAVCRLS VKFGATLRTS RLLLERAKEL NIDVVGVSFH VGSGCTDPET FVQAISDARC VFDMGAEVGF SMYLLDIGGG FPGSEDVKLK FEEITGVINP ALDKYFPSDS GVRIIAEPGR YYVASAFTLA VNIIAKKIVL KEQTGSDDED ESSEQTFMYY VNDGVYGSFN CILYDHAHVK PLLQKRPKPD EKYYSSSIWG PTCDGLDRIV ERCDLPEMHV GDWMLFENMG AYTVAAASTF NGFQRPTIYY VMSGPAWQLM QQFQNPDFPP EVEEQDASTL PVSCAWESGM KRHRAACASA SINV

purity :

> 95% by SDS - PAGE

form :

Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl

concentration :

0.5 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human. Tag: His-tag

other info2 :

Expression System: E Coli

products categories :

Metabolism

products description :

Ornithine decarboxylase, also known as ODC1, is the initial and rate-limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. ODC1 plays an important role in diverse biological processes, including cell growth, differentiation, transformation and apoptosis. Overexpression of the ODC1 gene plays important roles in cell proliferation and the development of cancer. Recombinant human ODC1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

products references :

Moshier J A., et al. (1992) Genomics. 1:77-86. Yang Feng T L., et al. (1996) Genomics. 36:449-458.

ncbi gi num :

4505489

ncbi acc num :

NP_002530

ncbi gb acc num :

NM_002539.2

ncbi mol weight :

53.5 kDa (484aa)

ncbi pathways :

Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Glutathione Metabolism Pathway (82973); Glutathione Metabolism Pathway (343); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169); Metabolism Of Polyamines Pathway (106193); Polyamine Biosynthesis, Arginine = Ornithine = Putrescine Pathway (413403); Polyamine Biosynthesis, Arginine = Ornithine = Putrescine Pathway (468321)

ncbi summary :

This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]

uniprot summary :

ODC: the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. [provided by RefSeq, Jul 2008]. Protein type: Other Amino Acids Metabolism - glutathione; EC 4.1.1.17; Cell cycle regulation; Lyase; Amino Acid Metabolism - arginine and proline. Chromosomal Location of Human Ortholog: 2p25. Cellular Component: cytoplasm; cytosol. Molecular Function: protein homodimerization activity; ornithine decarboxylase activity. Biological Process: response to virus; positive regulation of cell proliferation; regulation of protein catabolic process; kidney development; regulation of amino acid metabolic process; putrescine biosynthetic process from ornithine; polyamine metabolic process. Disease: Colorectal Cancer

size1 :

0.05 mg

price1 :

375 USD

size2 :

0.25 mg

price2 :

925

more info or order :

MyBioSource product webpage