product summary
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company name :
MyBioSource
product type :
protein
product name :
mutM, 1-269aa, E Coli, His tag, E Coli
catalog :
MBS204686
quantity :
0.05 mg
price :
375 USD
more info or order :
product information
catalog number :
MBS204686
products type :
Recombinant Protein
products full name :
mutM, 1-269aa, E Coli, His tag, E Coli
products short name :
mutM
products name syn :
Formamidopyrimidine-DNA glycosylase; fpg
other names :
formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Formamidopyrimidine-DNA glycosylase; formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase MutM (EC:4.2.99.18); AP lyase MutM
products gene name :
mutM
other gene names :
mutM; mutM; ECK3625; fpg; JW3610; fpg; Fapy-DNA glycosylase; AP lyase MutM
uniprot entry name :
FPG_ECOLI
sequence length :
269
sequence :
MGSSHHHHHH SSGLVPRGSH MPELPEVETS RRGIEPHLVG ATILHAVVRN GRLRWPVSEE IYRLSDQPVL SVQRRAKYLL LELPEGWIII HLGMSGSLRI LPEELPPEKH DHVDLVMSNG KVLRYTDPRR FGAWLWTKEL EGHNVLTHLG PEPLSDDFNG EYLHQKCAKK KTAIKPWLMD NKLVVGVGNI YASESLFAAG IHPDRLASSL SLAECELLAR VIKAVLLRSI EQGGTTLKDF LQSDGKPGYF AQELQVYGRK GEPCRVCGTP IVATKHAQRA TFYCRQCQK
purity :
> 90% by SDS - PAGE
form :
Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol 0.1M NaCl,1mM DTT
concentration :
0.5 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: E Coli. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Enzymes & Proteases
products description :
mutM, also known as formamidopyrimidine DNA glycosylase, is a base excision repair enzyme which recognizes and removes a wide range of oxidized purines from correspondingly damaged DNA. This protein is nonredundant and required to rapidly remove its substrate lesions on the chromosome. In addition, it also repaired a significant portion of the lesions recognized by Endo III, suggesting that it plays a prominent role in the global repair of both purine damage and pyrimidine damage in vivo. Recombinant E. coli mutM protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Serre L. et al. (2002) EMBO J. 21:2854-2865. Schalow BJ. et al. (2011) J Mol Biol, 410:183-193.
ncbi gi num :
16131506
ncbi acc num :
NP_418092
ncbi gb acc num :
NC_000913.3
uniprot acc num :
P05523
ncbi mol weight :
32.4 kDa (289aa), confirmed by MALDI-TOF
ncbi pathways :
Base Excision Repair Pathway (1126); Base Excision Repair Pathway (451)
ncbi summary :
MutM (also known as Fpg) is a DNA glycosylase that works in the base excision repair (BER) pathway to repair certain types of pre-mutagenic lesions. [More information is available at EcoCyc: EG10329].
size1 :
0.05 mg
price1 :
375 USD
size2 :
0.25 mg
price2 :
925
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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