HRP-Linked Polyclonal Antibody to Thioredoxin (Trx) | MyBioSource MBS2046307 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

HRP-Linked Polyclonal Antibody to Thioredoxin (Trx)

catalog :

MBS2046307

quantity :

0.1 mg

price :

255 USD

clonality :

polyclonal

host :

rabbit

conjugate :

HRP

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS2046307

products type :

Antibody

products full name :

HRP-Linked Polyclonal Antibody to Thioredoxin (Trx)

products short name :

[Thioredoxin (Trx)]

products name syn :

[TXN; ADF; SASP; TRDX; TRX1; ATL-derived factor; Surface-associated sulphydryl protein]

other names :

[thioredoxin; Thioredoxin; thioredoxin; thioredoxin 1]

products gene name :

[Trx]

other gene names :

[Txn1; Txn; Txn; Txn1; Trx]

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

purity :

Antigen-specific Affinity Chromatography

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

concentration :

200ug/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

WB; IHC; ICC

app notes :

Western blotting: 0.5-2ug/mL. Immunohistochemistry: 5-20ug/mL. Immunocytochemistry: 5-20ug/mL. Optimal working dilutions must be determined by end user

image1 heading :

Wetsern Blot

other info1 :

Source: Antibody labeling. Label: HRP. Traits: Liquid. Immunogen: Recombinant Thioredoxin (MET1~Val105) expressed in E.coli.

other info2 :

Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2001389

ncbi gi num :

16758644

ncbi acc num :

NP_446252.1

ncbi gb acc num :

NM_053800.3

ncbi pathways :

Cellular Senescence Pathway (935708); Cellular Responses To Stress Pathway (935701); Detoxification Of Reactive Oxygen Species Pathway (935707); Immune System Pathway (936650); Inflammasomes Pathway (936724); Innate Immune System Pathway (936679); Metabolism Pathway (935443); Metabolism Of Nucleotides Pathway (935606); NFE2L2 Pathway (739005); Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways (936722)

ncbi summary :

protein-disulfide reductase enzyme that is important for redox signalling during apoptosis and cell growth [RGD, Feb 2006]

uniprot summary :

TXN: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. In case of infection, interacts with S.typhimurium protein slrP. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA- binding activity in a redox-dependent manner. Up-regulated by ionizing radiation. Belongs to the thioredoxin family. Protein type: Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 5q24. Cellular Component: axon; cell soma; cytoplasm; cytosol; dendrite; mitochondrion; nucleus. Molecular Function: enzyme binding; oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor; peptide disulfide oxidoreductase activity; protein disulfide oxidoreductase activity; protein-disulfide reductase activity; thioredoxin-disulfide reductase activity. Biological Process: cell redox homeostasis; negative regulation of protein export from nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of DNA binding; positive regulation of peptidyl-serine phosphorylation; regulation of protein import into nucleus, translocation; response to activity; response to axon injury; response to drug; response to radiation; response to selenium ion

size1 :

0.1 mg

price1 :

255 USD

size2 :

0.2 mg

price2 :

395

size3 :

1 mg

price3 :

935

more info or order :

MyBioSource product webpage