product summary
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company name :
MyBioSource
product type :
protein
product name :
DSTN, 1-165aa, Human, His tag, E Coli
catalog :
MBS204618
quantity :
0.1 mg
price :
310 USD
more info or order :
product information
catalog number :
MBS204618
products type :
Recombinant Protein
products full name :
DSTN, 1-165aa, Human, His tag, E Coli
products short name :
DSTN
products name syn :
Destrin (actin depolymerizing factor); ACTDP; ADF; bA462D18.2
other names :
destrin isoform a; Destrin; destrin; actin-depolymerizing factor; bA462D18.2 (destrin (actin depolymerizing factor ADF) (ACTDP)); epididymis luminal protein 32; destrin (actin depolymerizing factor); Actin-depolymerizing factor; ADF
products gene name :
DSTN
other gene names :
DSTN; DSTN; ADF; ACTDP; HEL32; bA462D18.2; ACTDP; DSN; ADF
uniprot entry name :
DEST_HUMAN
sequence length :
165
sequence :
MASGVQVADE VCRIFYDMKV RKCSTPEEIK KRKKAVIFCL SADKKCIIVE EGKEILVGDV GVTITDPFKH FVGMLPEKDC RYALYDASFE TKESRKEELM FFLWAPELAP LKSKMIYASS KDAIKKKFQG IKHECQANGP EDLNRACIAE KLGGSLIVAF EGCPVLEHHH HHH
purity :
> 95% by SDS - PAGE
form :
Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol,1mM DTT
concentration :
0.5 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Actin & Myosin Related
products description :
Destrin (actin depolymerizing factor), also known as DSTN, is a member of the ADF/Cofilin/destrin superfamily that has the ability to rapidly depolymerize F-Actin in a stoichiometric manner. DSTN is a small phosphoinositide-sensitive actin-binding protein capable of depolymerizing actin-filaments in vitro. It is found in various epithelial and endothelial cells but is practically absent from adult mouse heart and skeletal muscle cells. DSTN shares 71% sequence homology with Cofilin, however the two proteins differ in their interaction with Actin. Recombinant human DSTN protein, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Nishida E., et al. (1985) Biochemistry. 24:6624-6630. Kanamori T., et al. (1995) J Biol Chem. 270: 8061-8067.
ncbi gi num :
5802966
ncbi acc num :
NP_006861
ncbi gb acc num :
NM_006870.3
ncbi mol weight :
19.5 kDa (173aa) confirmed by MALDI-TOF
ncbi pathways :
Androgen Receptor Signaling Pathway (198806)
ncbi summary :
The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
uniprot summary :
Destrin: an actin-depolymerizing cytoskeletal protein that belongs to the ADF actin-binding protein family. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Present in many vertebrate tissues and particularly abundant in neuronal cells. It binds F-actin in a pH-dependent manner which affects it s severing/depolymerizing activities. It also binds G-actin at pH 8.0 thereby sequestering monomers and preventing polymerization. Protein type: Motility/polarity/chemotaxis; Actin-binding. Chromosomal Location of Human Ortholog: 20p12.1. Cellular Component: cortical actin cytoskeleton; actin cytoskeleton. Molecular Function: actin binding. Biological Process: actin filament severing; actin filament depolymerization; positive regulation of actin filament depolymerization; actin polymerization and/or depolymerization
size1 :
0.1 mg
price1 :
310 USD
size2 :
0.5 mg
price2 :
720
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
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