protein

CD274, 19-239aa, Mouse, His tag, E Coli

MBS204606

0.1 mg

310 USD

Recombinant Protein

CD274, 19-239aa, Mouse, His tag, E Coli

CD274

CD274 antigen; A530045L16Rik; B7h1; Pdcd1l1; Pdcd1lg1; Pdl1

programmed cell death 1 ligand 1; Programmed cell death 1 ligand 1; programmed cell death 1 ligand 1; B7 homolog 1; PDCD1 ligand 1; programmed death ligand 1; CD274 antigen; B7 homolog 1; B7-H1; CD_antigen: CD274

CD274

Cd274; Cd274; B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik; B7h1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; B7-H1

PD1L1_MOUSE

290

MGSSHHHHHH SSGLVPRGSH MGSHMFTITA PKDLYVVEYG SNVTMECRFP VERELDLLAL VVYWEKEDEQ VIQFVAGEED LKPQHSNFRG RASLPKDQLL KGNAALQITD VKLQDAGVYC CIISYGGADY KRITLKVNAP YRKINQRISV DPATSEHELI CQAEGYPEAE VIWTNSDHQP VSGKRSVTTS RTEGMLLNVT SSLRVNATAN DVFYCTFWRS QPGQNHTAEL IIPELPATHP PQNRTH

> 85% by SDS - PAGE

Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 0.15M NaCl

1 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Mouse. Tag: His-tag

Expression System: E Coli

Immunology

CD274, also known as programmed cell death 1 ligand 1(PDCD1L1), is involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. This protein interacts with PDCD1 inhibits T-cell proliferation and cytokine production. Recombinant mouse CD274 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Li,X., et al. (2012) J. Immunol. 188 (2), 724-734. Pulko,V., et al. (2011) J. Immunol. 187 (11), 5606-5614

11230798

NP_068693

NM_021893.3

27.6kDa(246aa), confirmed by MALDI-TOF. (Molecular size on SDS-PAGE will appear higher)

Adaptive Immune System Pathway (1110669); Cell Adhesion Molecules (CAMs) Pathway (83266); Cell Adhesion Molecules (CAMs) Pathway (480); Costimulation By The CD28 Family Pathway (1110675); Immune System Pathway (1110668); PD-1 Signaling Pathway (1110680)

CD274: Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; external side of plasma membrane. Molecular Function: protein binding. Biological Process: cell surface receptor linked signal transduction; negative regulation of T cell proliferation; negative regulation of interleukin-10 production; negative regulation of interferon-gamma production; negative regulation of activated T cell proliferation; T cell costimulation; positive regulation of T cell proliferation; immune response; signal transduction; positive regulation of cell migration

0.1 mg

310 USD

0.5 mg

720