protein

FGFR1OP, 1-379aa, Human, His tag, E Coli

MBS204597

0.05 mg

375 USD

Recombinant Protein

FGFR1OP, 1-379aa, Human, His tag, E Coli

FGFR1OP

FGFR1 oncogene partner; FOP

FGFR1 oncogene partner isoform b; FGFR1 oncogene partner; FGFR1 oncogene partner; fibroblast growth factor receptor 1 oncogene partner; FGFR1 oncogene partner

FGFR1OP

FGFR1OP; FGFR1OP; FOP; FOP

FR1OP_HUMAN

379

MGSSHHHHHH SSGLVPRGSH MGSHMAATAA AVVAEEDTEL RDLLVQTLEN SGVLNRIKAE LRAAVFLALE EQEKVENKTP LVNESLKKFL NTKDGRLVAS LVAEFLQFFN LDFTLAVFQP ETSTLQGLEG RENLARDLGI IEAEGTVGGP LLLEVIRRCQ QKEKGPTTGE GALDLSDVHS PPKSPEGKTS AQTTPSKKAN DEANQSDTSV SLSEPKSKSS LHLLSHETKI GSFLSNRTLD GKDKAGLCPD EDDMEGDSFF DDPIPKPEKT YGLRKEPRKQ AGSLASLSDA PPLKSGLSSL AGAPSLKDSE SKRGNTVLKD LKLISDKIGS LGLGTGEDDD YVDDFNSTSH RSEKSEISIG EEIEEDLSVE IDDINTSDKL DDLTQDLTVS QLSDVADYLE DVA

> 85% by SDS - PAGE

Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 1mM DTT

1mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Cell Cycle

FGFR1OP, also known as FGFR1 oncogene partner, belongs to the FGFR1OP family. This protein is a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Recombinant human FGFR1OP protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Yan X., et al. (2006) Mol. Biol. Cell. 17:634-644. Mikolajka A., et al. (2006) J. Mol. Biol. 359:863-875

36287110

NP_919410

NM_194429.2

43.5 kDa (403aa), confirmed by MALDI-TOF

Anchoring Of The Basal Body To The Plasma Membrane Pathway 1127503!!Assembly Of The Primary Cilium Pathway 1127502!!Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765!!Centrosome Maturation Pathway 105807!!Disease Pathway 530764!!G2/M Transition Pathway 105801!!Loss Of Nlp From Mitotic Centrosomes Pathway 105811!!Loss Of Proteins Required For Interphase Microtubule Organizationfrom The Centrosome Pathway 105810!!Mitotic G2-G2/M Phases Pathway 160942

This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]

0.05 mg

375 USD