protein

LGALS1, 1-135aa, mouse, His tag, E Coli

MBS204559

0.1 mg

310 USD

Recombinant Protein

LGALS1, 1-135aa, mouse, His tag, E Coli

LGALS1

Galectin-1; AA410090; Gal-1; Galbp; galectin-1; L-14.5; L14; Lect14

galectin-1; Galectin-1; galectin-1; 14 kDa lectin; S-Lac lectin 1; beta-galactoside binding protein; beta-galactoside-binding lectin L-14-I; galaptin; lactose-binding lectin 1; lectin galactoside-binding soluble 1; lectin, galactose binding, soluble 1; 14 kDa lectin; Beta-galactoside-binding lectin L-14-I; Galaptin; Lactose-binding lectin 1; Lectin galactoside-binding soluble 1; S-Lac lectin 1

LGALS1

Lgals1; Lgals1; L14; Gal-1; Galbp; L-14.5; Lect14; AA410090; galectin-1; Gbp; Gal-1

LEG1_MOUSE

135

MGSSHHHHHH SSGLVPRGSH MGSHMACGLV ASNLNLKPGE CLKVRGEVAS DAKSFVLNLG KDSNNLCLHF NPRFNAHGDA NTIVCNTKED GTWGTEHREP AFPFQPGSIT EVCITFDQAD LTIKLPDGHE FKFPNRLNME AINYMAADGD FKIKCVAFE

> 95% by SDS - PAGE

Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol

1 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Mouse. Tag: His-tag

Expression System: E Coli

Cell Cycle

LGALS1 is a member of the beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This protein is an autocrine negative growth factor that regulates cell proliferation. It controls cell survival by inducing apoptosis of activated T cells and immature thymocytes, thus LGALS1 has immunosuppressive and anti-inflammatory properties. LGALS1 also regulates tumor angiogenesis and is a target for angiostatic cancer therapy. Recombinant mouse LGALS1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques

Ilarregui JM., et al. (2009). Nat Immunol. 10(9):981-91. Gauthier L., Proc Natl Acad Sci u S A. 2002 Oct 1;99(20):13014-9.

6678682

NP_032521

NM_008495.2

17 kDa (159aa), confirmed by MALDI-TOF

PodNet: Protein-protein Interactions In The Podocyte Pathway (755428); XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway (755427)

Galectin-1: May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (via poly-N- acetyllactosamine). Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion. Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells. Protein type: Cell adhesion. Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; cell surface; cytoplasm; extracellular region; intracellular; nucleus. Molecular Function: signal transducer activity; protein binding; protein homodimerization activity; lactose binding; galactose binding; galactoside binding; laminin binding; carbohydrate binding; glycoprotein binding. Biological Process: myoblast differentiation; heterophilic cell adhesion; plasma cell differentiation; positive regulation of I-kappaB kinase/NF-kappaB cascade; apoptosis; T cell costimulation; positive regulation of erythrocyte aggregation; signal transduction

0.1 mg

310 USD

0.5 mg

720