catalog number :
MBS204541
products type :
Recombinant Protein
products full name :
ESAT6, 1-95aa, Mycobacterium tuberculosis, His tag, Baculovirus
products short name :
ESAT6
products name syn :
Early secretory antigenic target; 6 kDa
other names :
early secretory antigenic target, 6 kDa; early secretory antigenic target, 6 kDa
products gene name :
ESAT6
other gene names :
MT3989
sequence :
ADPMTEQQWN FAGIEAAASA IQGNVTSIHS LLDEGKQSLT KLAAAWGGSG SEAYQGVQQK WDATATELNN ALQNLARTIS EAGQAMASTE GNVTGMFAHH HHHH
purity :
> 90% by SDS - PAGE
form :
Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing, 10% glycerol
concentration :
0.5 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Mycobacterium tuberculosis. Tag: His-tag
other info2 :
Expression System: Hi-5. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)
products description :
ESAT6, the 6 kDa early secretory antigenic target of Mycobacterium tuberculosis, is a secretory protein and potent T cell antigen. ESAT6 has been shown to directly bind to the TLR2 receptor, inhibiting downstream signal transduction. Recently it was shown that ESAT6 is very potential as diagnostic for differentiation between the mycobacterial infection and BCG vaccination. Recombinant Mycobacterium tuberculosis CDC1551 ESAT6 protein, fused to His-tag at C-terminus, was expressed in Baculovirus and purified by using conventional chromatography techniques.
products references :
Pathak SK., et al. (2007) Natlmmunol. 8(6):610-8. Matveeva NA., et al. (2011) Tsitol Genet. 45(1):11-7.
ncbi acc num :
NP_338543.1
ncbi gb acc num :
NC_002755.2
ncbi mol weight :
11 kDa (104aa)
ncbi pathways :
Tuberculosis Pathway (213746); Tuberculosis Pathway (213743)