STAR, 64-285aa, Human, His tag E Coli | MyBioSource MBS204495 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

STAR, 64-285aa, Human, His tag E Coli

catalog :

MBS204495

quantity :

0.1 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS204495

products type :

Recombinant Protein

products full name :

STAR, 64-285aa, Human, His tag E Coli

products short name :

STAR

products name syn :

Steroidogenic acute regulatory protein; mitochondrial

other names :

steroidogenic acute regulatory protein, mitochondrial; Steroidogenic acute regulatory protein, mitochondrial; steroidogenic acute regulatory protein, mitochondrial; START domain containing 1; START domain-containing protein 1; StAR-related lipid transfer (START) domain containing 1; cholesterol trafficker; mitochondrial steroid acute regulatory protein; steroidogenic acute regulatory protein; START domain-containing protein 1; StARD1

products gene name :

STAR

other gene names :

STAR; STAR; STARD1; STARD1; StAR; StARD1

uniprot entry name :

STAR_HUMAN

sequence length :

285

sequence :

MGSSHHHHHH SSGLVPRGSH MEETLYSDQE LAYLQQGEEA MQKALGILSN QEGWKKESQQ DNGDKVMSKV VPDVGKVFRL EVVVDQPMER LYEELVERME AMGEWNPNVK EIKVLQKIGK DTFITHELAA EAAGNLVGPR DFVSVRCAKR RGSTCVLAGM ATDFGNMPEQ KGVIRAEHGP TCMVLHPLAG SPSKTKLTWL LSIDLKGWLP KSIINQVLSQ TQVDFANHLR KRLESHPASE ARC

purity :

> 90% by SDS - PAGE

form :

Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 2mM DTT

concentration :

1.0 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human. Tag: His-tag

other info2 :

Expression System: E Coli

products categories :

Cancer

products description :

STAR, also known as steroidogenic acute regulatory protein, appears to mediate the rapid increase in pregnenolone synthesis stimulated by tropic hormones. It increases pregnenolone synthesis more than four-fold and a major STAR transcript of 1.6 kb is found in ovary and testis. During ongoing growth and differentiation of the follicle of the ovary, the immunoreactivity of it tends to shift from the granulosa cells of early antral follicles to the theca cell layers in the adult. Recombinant human STAR protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

products references :

Borthwick F. et al. (2009) FEBS Lett. 583:1147-1153. Mikhaylova I.V. et al. (2008) J. Endocrinol.199: 435-444.

ncbi gi num :

56243551

ncbi acc num :

NP_000340

ncbi gb acc num :

NM_000349.2

ncbi mol weight :

27.1 kDa (243aa), confirmed by MALDI-TOF

ncbi pathways :

Corticotropin-releasing Hormone Pathway (920957); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Metabolism Of Steroid Hormones And Vitamin D Pathway (106150); Ovarian Steroidogenesis Pathway (790011); Ovarian Steroidogenesis Pathway (795173); Pregnenolone Biosynthesis Pathway (106151)

ncbi summary :

The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008]

uniprot summary :

STAR: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. May interact with TSPO. Expressed in gonads, adrenal cortex and kidney. Protein type: Lipid-binding; Mitochondrial; Carrier. Chromosomal Location of Human Ortholog: 8p11.2. Cellular Component: mitochondrial crista; neuron projection; cell soma; mitochondrial intermembrane space; cytosol. Molecular Function: cholesterol transporter activity; cholesterol binding. Biological Process: response to nicotine; steroid metabolic process; diterpenoid metabolic process; dibenzo-p-dioxin metabolic process; regulation of steroid biosynthetic process; estrogen biosynthetic process; biphenyl metabolic process; circadian sleep/wake cycle, REM sleep; negative regulation of neuron apoptosis; response to nutrient; response to corticosterone stimulus; response to drug; bile acid biosynthetic process; cholesterol metabolic process; positive regulation of neurogenesis; progesterone biosynthetic process; insecticide metabolic process; fractalkine metabolic process; male gonad development; phthalate metabolic process; intracellular cholesterol transport; response to herbicide; glucocorticoid metabolic process; response to ethanol; response to hydrogen peroxide; cellular response to insulin stimulus; response to estrogen stimulus; response to lead ion; C21-steroid hormone biosynthetic process; response to activity; response to ionizing radiation; brain development; steroid biosynthetic process; phenol metabolic process; regulation of neuronal synaptic plasticity. Disease: Lipoid Congenital Adrenal Hyperplasia

size1 :

0.1 mg

price1 :

310 USD

size2 :

0.5 mg

price2 :

720

more info or order :

MyBioSource product webpage