product summary
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company name :
MyBioSource
product type :
protein
product name :
DTYMK, 1-212aa, Human, His tag, E Coli
catalog :
MBS204368
quantity :
0.1 mg
price :
310 USD
more info or order :
product information
catalog number :
MBS204368
products type :
Recombinant Protein
products full name :
DTYMK, 1-212aa, Human, His tag, E Coli
products short name :
DTYMK
products name syn :
Thymidylate kinase; CDC8; FLJ44192; MGC198617; PP3731; TMPK; TYMK
other names :
thymidylate kinase isoform 1; Thymidylate kinase; thymidylate kinase; dTMP kinase; deoxythymidylate kinase (thymidylate kinase); dTMP kinase
products gene name :
DTYMK
other gene names :
DTYMK; DTYMK; CDC8; TMPK; TYMK; PP3731; CDC8; TMPK; TYMK
uniprot entry name :
KTHY_HUMAN
sequence length :
212
sequence :
MGSSHHHHHH SSGLVPRGSH MAARRGALIV LEGVDRAGKS TQSRKLVEAL CAAGHRAELL RFPERSTEIG KLLSSYLQKK SDVEDHSVHL LFSANRWEQV PLIKEKLSQG VTLVVDRYAF SGVAFTGAKE NFSLDWCKQP DVGLPKPDLV LFLQLQLADA AKRGAFGHER YENGAFQERA LRCFHQLMKD TTLNWKMVDA SKSIEAVHED IRVLSEDAIR TATEKPLGEL WK
purity :
> 95 % by SDS - PAGE
form :
Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 20% glycerol, 2mM DTT, 0.1M NaCl
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Cell Cycle
products description :
DTYMK is also known as thymidylate kinase family and is involved in pyrimidine metabolism. Specifically, DTYMK catalyzes the ATP-dependent conversion of dTMP (deoxythymidine monophosphate) to dTDP (deoxythymidine diphosphate), which then functions as one of the four nucleotides in DNA. Via its role in the catalytic creation of dTDP, DTYMK plays an important role in the pathway of DNA synthesis and is thought to be involved in cell cycle progression and cell growth. Recombinant human DTYMK protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Cummins RR., et al. (1980) Cancer Res. 40(4):1235-9. Su JY., et al. (1991) Nucleic Acids Res. 19(4):823-7.
ncbi gi num :
42544174
ncbi acc num :
NP_036277
ncbi gb acc num :
NM_012145.3
ncbi mol weight :
26 kDa (232aa), confirmed by MALDI-TOF
ncbi pathways :
Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Nucleotides Pathway (106263); Pyrimidine Metabolism Pathway (82946); Pyrimidine Metabolism Pathway (309); Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway (161057); Pyrimidine Deoxyribonucleotide Phosphorylation Pathway (782379); Pyrimidine Deoxyribonucleotide Phosphorylation Pathway (907959); Pyrimidine Deoxyribonucleotides Biosynthesis From CTP Pathway (782381); Pyrimidine Deoxyribonucleotides Biosynthesis From CTP Pathway (907956)
uniprot summary :
DTYMK: Catalyzes the conversion of dTMP to dTDP. Belongs to the thymidylate kinase family. Protein type: Mitochondrial; Kinase, other; EC 2.7.4.9; Nucleotide Metabolism - pyrimidine. Chromosomal Location of Human Ortholog: 2q37.3. Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial intermembrane space; cytosol; nucleus. Molecular Function: thymidylate kinase activity; uridylate kinase activity; nucleoside phosphate kinase activity; ATP binding. Biological Process: myoblast differentiation; cell proliferation; response to cadmium ion; response to estrogen stimulus; nucleobase, nucleoside and nucleotide interconversion; nucleoside monophosphate phosphorylation; nucleobase, nucleoside and nucleotide metabolic process; dUDP biosynthetic process; dTDP biosynthetic process; dTTP biosynthetic process; cell cycle; nucleotide phosphorylation
size1 :
0.1 mg
price1 :
310 USD
size2 :
0.5 mg
price2 :
720
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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