catalog number :
MBS204340
products type :
Recombinant Protein
products full name :
LRPAP1, 35-357aa, Human, His tag, E Coli
products short name :
LRPAP1
products name syn :
alpha-2-macroglobulin receptor-associated protein; A2MRAP; A2RAP; HBP44; MGC138272; MRAP; RAP
other names :
alpha-2-macroglobulin receptor-associated protein; Alpha-2-macroglobulin receptor-associated protein; alpha-2-macroglobulin receptor-associated protein; 39 kDa receptor-associated protein; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1); low density lipoprotein receptor-related protein associated protein 1; Low density lipoprotein receptor-related protein-associated protein 1; RAP
products gene name :
LRPAP1
other gene names :
LRPAP1; LRPAP1; RAP; MRAP; A2RAP; HBP44; MYP23; A2MRAP; alpha-2-MRAP; A2MRAP; Alpha-2-MRAP; RAP
uniprot entry name :
AMRP_HUMAN
sequence :
MGSSHHHHHH SSGLVPRGSH MGSHMYSREK NQPKPSPKRE SGEEFRMEKL NQLWEKAQRL HLPPVRLAEL HADLKIQERD ELAWKKLKLD GLDEDGEKEA RLIRNLNVIL AKYGLDGKKD ARQVTSNSLS GTQEDGLDDP RLEKLWHKAK TSGKFSGEEL DKLWREFLHH KEKVHEYNVL LETLSRTEEI HENVISPSDL SDIKGSVLHS RHTELKEKLR SINQGLDRLR RVSHQGYSTE AEFEEPRVID LWDLAQSANL TDKELEAFRE ELKHFEAKIE KHNHYQKQLE IAHEKLRHAE SVGDGERVSR SREKHALLEG RTKELGYTVK KHLQDLSGRI SRARHNEL
purity :
> 90% by SDS - PAGE
form :
Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 1mM DTT
concentration :
1.0 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Metabolism
products description :
LRPAP1, also known as alpha-2-macroglobulin receptor-associated protein, belongs to the alpha-2-MRAP family. This protein interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. It is present on the cell surface forming a complex with the alpha 2 macroglobulin receptor heavy and light chains In complex with the alpha 2 MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis Recombinant human LRPAP1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
products references :
Vash B. et al. (1998) Blood 92: 3277-3285. Trommsdorff M. et al. (1999) Cell 97: 689-701.
ncbi gb acc num :
NM_002337.3
ncbi mol weight :
40.4 kDa(348aa) confirmed by MALDI-TOF
ncbi pathways :
Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway 137984!!Reelin Signaling Pathway 137980!!Signaling Events Mediated By The Hedgehog Family Pathway 137950
ncbi summary :
This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]