EFNB3, 28-226aa Human, His tag, E Coli | MyBioSource MBS204329 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

EFNB3, 28-226aa Human, His tag, E Coli

catalog :

MBS204329

quantity :

0.1 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS204329

products type :

Recombinant Protein

products full name :

EFNB3, 28-226aa Human, His tag, E Coli

products short name :

EFNB3

products name syn :

Ephrin-B3; EFL6; EPLG8; LERK8

other names :

ephrin-B3; Ephrin-B3; ephrin-B3; EPH-related receptor transmembrane ligand ELK-L3; Ephrin B3; eph-related receptor tyrosine kinase ligand 8; ephrin-B3; EPH-related receptor transmembrane ligand ELK-L3; EPH-related receptor tyrosine kinase ligand 8; LERK-8

products gene name :

EFNB3

other gene names :

EFNB3; EFNB3; EFL6; EPLG8; LERK8; EPLG8; LERK8; LERK-8

uniprot entry name :

EFNB3_HUMAN

sequence length :

340

sequence :

MGSSHHHHHH SSGLVPRGSH MGSHMLSLEP VYWNSANKRF QAEGGYVLYP QIGDRLDLLC PRARPPGPHS SPNYEFYKLY LVGGAQGRRC EAPPAPNLLL TCDRPDLDLR FTIKFQEYSP NLWGHEFRSH HDYYIIATSD GTREGLESLQ GGVCLTRGMK VLLRVGQSPR GGAVPRKPVS EMPMERDRGA AHSLEPGKEN LPGDPTSNAT SRGAEGPLPP PSMP

purity :

> 90% by SDS - PAGE

form :

Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 0.1M NaCl, 2M urea

concentration :

1 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human. Tag: His-tag

other info2 :

Expression System: E Coli

products categories :

Neuroscience

products description :

EFNB3, also known as ephrin-B3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. It binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. Recombinant human EFNB3 protein, fused to His-tag at N-terminus, was expressed in E.coli.

products references :

Negrete O.A., et al. (2006) PLoS Pathog. 2:78-86. Brueckner K., et al. (1999) Neuron. 22:511-524

ncbi gi num :

4503489

ncbi acc num :

NP_001397

ncbi gb acc num :

NM_001406.3

ncbi mol weight :

24.6 kDa (224aa)

ncbi pathways :

Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); EPH-Ephrin Signaling Pathway (1127691); EPH-ephrin Mediated Repulsion Of Cells Pathway (1127695); EPHB Forward Signaling Pathway (138047); EPHB-mediated Forward Signaling Pathway (1127693); Ephrin Signaling Pathway (1127694)

ncbi summary :

EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]

uniprot summary :

EFNB3: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons. Belongs to the ephrin family. Protein type: Ligand, receptor tyrosine kinase; Membrane protein, integral; Cell development/differentiation. Chromosomal Location of Human Ortholog: 17p13.1. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: ephrin receptor binding; transmembrane-ephrin receptor activity. Biological Process: nervous system development; axon guidance; viral reproduction; cell-cell signaling; axon choice point recognition; ephrin receptor signaling pathway; adult walking behavior

size1 :

0.1 mg

price1 :

310 USD

size2 :

0.5 mg

price2 :

720

more info or order :

MyBioSource product webpage