catalog number :
MBS204315
products type :
Recombinant Protein
products full name :
MAPRE2, 1-327aa, Human, His tag, E Coli
products short name :
MAPRE2
products name syn :
Microtubule-associated protein; RP/EB family member 2; EB1; EB2; RP1
other names :
microtubule-associated protein RP/EB family member 2 isoform 1; Microtubule-associated protein RP/EB family member 2; microtubule-associated protein RP/EB family member 2; APC-binding protein EB1; APC-binding protein EB2; T-cell activation protein, EB1 family; end-binding protein 2; microtubule-associated protein, RP/EB family, member 2; APC-binding protein EB2; End-binding protein 2; EB2
products gene name :
MAPRE2
other gene names :
MAPRE2; MAPRE2; EB1; EB2; RP1; RP1; EB2
uniprot entry name :
MARE2_HUMAN
sequence :
MGSSHHHHHH SSGLVPRGSH MPGPTQTLSP NGENNNDIIQ DNNGTIIPFR KHTVRGERSY SWGMAVNVYS TSITQETMSR HDIIAWVNDI VSLNYTKVEQ LCSGAAYCQF MDMLFPGCIS LKKVKFQAKL EHEYIHNFKL LQASFKRMNV DKVIPVEKLV KGRFQDNLDF IQWFKKFYDA NYDGKEYDPV EARQGQDAIP PPDPGEQIFN LPKKSHHANS PTAGAAKSSP AAKPGSTPSR PSSAKRASSS GSASKSDKDL ETQVIQLNEQ VHSLKLALEG VEKERDFYFG KLREIELLCQ EHGQENDDLV QRLMDILYAS EEHEGHTEEP EAEEQAHEQQ PPQQEEY
purity :
> 85% by SDS - PAGE
form :
Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Cytoskeleton
products description :
MAPRE2, also known as RP1 or EB2, is evolutionarily conserved proteins, which associate with the tips of growing microtubules, and regulate microtubule dynamics and their interactions with intracellular structures. It has been shown that EB proteins regulate microtubule function through CLIP proteins. Recombinant human MAPRE2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
products references :
Renner C., et al. (1997) J. Immunol. 159:1279-1283. Bu W., et al. (2003) J. Biol. Chem. 278:49721-49731
ncbi gb acc num :
NM_014268.3
ncbi mol weight :
39.2 kDa (347aa), confirmed by MALDI-TOF
ncbi summary :
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]