C4BPB, 18-252aa, Human, His tag, E Coli | MyBioSource MBS204310 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

C4BPB, 18-252aa, Human, His tag, E Coli

catalog :

MBS204310

quantity :

0.1 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS204310

products type :

Recombinant Protein

products full name :

C4BPB, 18-252aa, Human, His tag, E Coli

products short name :

C4BPB

products name syn :

Complement component 4 binding protein; beta; C4BP

other names :

C4b-binding protein beta chain isoform 1; C4b-binding protein beta chain; C4b-binding protein beta chain; complement component 4 binding protein, beta

products gene name :

C4BPB

other gene names :

C4BPB; C4BPB; C4BP

uniprot entry name :

C4BPB_HUMAN

sequence length :

252

sequence :

MGSSHHHHHH SSGLVPRGSH MGSHMSDAEH CPELPPVDNS IFVAKEVEGQ ILGTYVCIKG YHLVGKKTLF CNASKEWDNT TTECRLGHCP DPVLVNGEFS SSGPVNVSDK ITFMCNDHYI LKGSNRSQCL EDHTWAPPFP ICKSRDCDPP GNPVHGYFEG NNFTLGSTIS YYCEDRYYLV GVQEQQCVDG EWSSALPVCK LIQEAPKPEC EKALLAFQES KNLCEAMENF MQQLKESGMT MEELKYSLEL KKAELKAKLL

purity :

> 90% by SDS - PAGE

form :

Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 0.15M NaCl

concentration :

1 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human. Tag: His-tag

other info2 :

Expression System: E Coli

products categories :

Immunology

products description :

C4BPB is a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain of this protein assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. Recombinant human C4BPB protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

products references :

Carlsson,S.et al. (2010) J. Biol. Chem. 285 (42), 32038-32046. Buil,A., et al. (2010) Blood 115 (23), 4644-4650

ncbi gi num :

4502505

ncbi acc num :

NP_000707

ncbi gb acc num :

NM_000716.3

ncbi mol weight :

29.0kDa(260aa), confirmed by MALDI-TOF

ncbi pathways :

Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); FOXA1 Transcription Factor Network Pathway (137979); Immune System Pathway (106386); Innate Immune System Pathway (106387); Pertussis Pathway (218111); Pertussis Pathway (218099); Regulation Of Complement Cascade Pathway (576254)

ncbi summary :

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008]

uniprot summary :

C4BPB: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: extracellular space; plasma membrane; extracellular region. Molecular Function: protein binding. Biological Process: negative regulation of complement activation, classical pathway; regulation of complement activation; positive regulation of protein catabolic process; innate immune response; blood coagulation; complement activation, classical pathway

size1 :

0.1 mg

price1 :

310 USD

size2 :

0.5 mg

price2 :

720

more info or order :

MyBioSource product webpage