F11R, 26-238aa, Human, His tag, E Coli | MyBioSource MBS204189 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

F11R, 26-238aa, Human, His tag, E Coli

catalog :

MBS204189

quantity :

0.1 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS204189

products type :

Recombinant Protein

products full name :

F11R, 26-238aa, Human, His tag, E Coli

products short name :

F11R

products name syn :

Junctional adhesion molecule A; CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1

other names :

junctional adhesion molecule A; Junctional adhesion molecule A; junctional adhesion molecule A; junctional adhesion molecule 1; platelet F11 receptor; platelet adhesion molecule 1; F11 receptor; Junctional adhesion molecule 1; JAM-1; Platelet F11 receptor; Platelet adhesion molecule 1; PAM-1; CD_antigen: CD321

products gene name :

F11R

other gene names :

F11R; F11R; JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1; JAM1; JCAM; JAM-A; JAM-1; PAM-1

uniprot entry name :

JAM1_HUMAN

sequence length :

299

sequence :

MGSSHHHHHH SSGLVPRGSH MGSHMLGSVT VHSSEPEVRI PENNPVKLSC AYSGFSSPRV EWKFDQGDTT RLVCYNNKIT ASYEDRVTFL PTGITFKSVT REDTGTYTCM VSEEGGNSYG EVKVKLIVLV PPSKPTVNIP SSATIGNRAV LTCSEQDGSP PSEYTWFKDG IVMPTNPKST RAFSNSSYVL NPTTGELVFD PLSASDTGEY SCEARNGYGT PMTSNAVRME AVERNVGV

purity :

> 90% by SDS - PAGE

form :

Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.15M NaCl,1mM DTT

concentration :

1 mg/ml (determined by BCA assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human. Tag: His-tag

other info2 :

Expression System: E Coli

products categories :

Cytoskeleton

products description :

F11R, also known as CD321, belongs to the immunoglobulin superfamily. It seems to plays a role in epithelial tight junction formation. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. F11R protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Recombinant human F11R protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

products references :

Murakami,M., et al. (2011) PLoS ONE 6 (6), E21242

ncbi gi num :

8393638

ncbi acc num :

NP_058642

ncbi gb acc num :

NM_016946.4

ncbi mol weight :

25.8kDa (238aa), confirmed by MALDI-TOF

ncbi pathways :

Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Junction Organization Pathway (160966); Cell Surface Interactions At The Vascular Wall Pathway (106062); Cell-Cell Communication Pathway (477132); Cell-cell Junction Organization Pathway (119532); Disease Pathway (530764); Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway (83102); Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway (515); Extracellular Matrix Organization Pathway (576262)

ncbi summary :

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

uniprot summary :

JAM-A: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus. Belongs to the immunoglobulin superfamily. Protein type: Membrane protein, integral; Cell adhesion. Chromosomal Location of Human Ortholog: 1q21.2-q21.3. Cellular Component: microtubule cytoskeleton; tight junction; integral to membrane; plasma membrane; intercellular junction; cytoplasmic vesicle; cell junction. Molecular Function: protein binding; PDZ domain binding. Biological Process: intercellular junction assembly and maintenance; extracellular matrix organization and biogenesis; response to radiation; viral reproduction; transforming growth factor beta receptor signaling pathway; actomyosin structure organization and biogenesis; cell adhesion; blood coagulation; inflammatory response; leukocyte migration; positive regulation of blood pressure; intestinal absorption

size1 :

0.1 mg

price1 :

310 USD

size2 :

0.5 mg

price2 :

720

more info or order :

MyBioSource product webpage