TCEB1, 1-112aa, Human, His tag E Coli | MyBioSource MBS204176 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

TCEB1, 1-112aa, Human, His tag E Coli

catalog :

MBS204176

quantity :

0.1 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS204176

products type :

Recombinant Protein

products full name :

TCEB1, 1-112aa, Human, His tag E Coli

products short name :

TCEB1

products name syn :

Transcription elongation factor B polypeptide 1; SIII; Elongin-C

other names :

transcription elongation factor B polypeptide 1 isoform a; Transcription elongation factor B polypeptide 1; transcription elongation factor B polypeptide 1; RNA polymerase II transcription factor SIII subunit C; SIII p15; elongin 15 kDa subunit; transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C); Elongin 15 kDa subunit; Elongin-C; EloC; RNA polymerase II transcription factor SIII subunit C; SIII p15

products gene name :

TCEB1

other gene names :

TCEB1; TCEB1; SIII; eloC; EloC

uniprot entry name :

ELOC_HUMAN

sequence length :

112

sequence :

MGSSHHHHHH SSGLVPRGSH MDGEEKTYGG CEGPDAMYVK LISSDGHEFI VKREHALTSG TIKAMLSGPG QFAENETNEV NFREIPSHVL SKVCMYFTYK VRYTNSSTEI PEFPIAPEIA LELLMAANFL DC

purity :

> 90% by SDS - PAGE

form :

Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 1mM DTT, 0.15M NaCl.

concentration :

0.5 mg/ml (determined by Bradford)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human. Tag: His-tag

other info2 :

Expression System: E Coli

products categories :

Transcription & Translation

products description :

TCEB1 (elongin C) is a subunit of elongin, which is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template encoded arresting sites. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau(VHL) tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Recombinant human TCEB1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

products references :

Duan DR., et al. (1995) Science. 269(5229):1402-6. Aso T., et al. (1995) Science. 269(5229):1439-43.

ncbi gi num :

5032161

ncbi acc num :

NP_005639

ncbi gb acc num :

NM_005648.3

ncbi mol weight :

14.6 kDa (132aa), confirmed by MALDI-TOF

ncbi pathways :

Adaptive Immune System Pathway (366160); Antigen Processing: Ubiquitination Proteasome Degradation Pathway (366162); Cellular Response To Hypoxia Pathway (645259); Cellular Responses To Stress Pathway (645258); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Disease Pathway (530764); ECS Complex Pathway (413455); ECS Complex Pathway (468394); ECV Complex Pathway (413450); ECV Complex Pathway (890606)

ncbi summary :

This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

uniprot summary :

TCEB1: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). Belongs to the SKP1 family. Protein type: Transcription initiation complex. Chromosomal Location of Human Ortholog: 8q21.11. Cellular Component: nucleoplasm; VCB complex; cytosol. Molecular Function: protein binding; protein complex binding. Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; ubiquitin-dependent protein catabolic process; viral reproduction; positive regulation of viral transcription; positive regulation of RNA elongation from RNA polymerase II promoter; RNA elongation from RNA polymerase II promoter; gene expression

size1 :

0.1 mg

price1 :

310 USD

size2 :

0.5 mg

price2 :

720

more info or order :

MyBioSource product webpage