catalog number :
MBS204141
products type :
Recombinant Protein
products full name :
FAM3C, 25-227aa, Human, His tag, E Coli
products short name :
FAM3C
products name syn :
Protein FAM3C; ILEI
other names :
protein FAM3C; Protein FAM3C; protein FAM3C; interleukin-like EMT inducer; interleukin-like epithelial-mesenchymal transition inducer; predicted osteoblast protein; family with sequence similarity 3, member C; Interleukin-like EMT inducer
products gene name :
FAM3C
other gene names :
FAM3C; FAM3C; ILEI; GS3786; ILEI
uniprot entry name :
FAM3C_HUMAN
sequence :
MGSSHHHHHH SSGLVPRGSH MQVFEIKMDA SLGNLFARSA LDTAARSTKP PRYKCGISKA CPEKHFAFKM ASGAANVVGP KICLEDNVLM SGVKNNVGRG INVALANGKT GEVLDTKYFD MWGGDVAPFI EFLKAIQDGT IVLMGTYDDG ATKLNDEARR LIADLGSTSI TNLGFRDNWV FCGGKGIKTK SPFEQHIKNN KDTNKYEGWP EVVEMEGCIP QKQD
purity :
> 90% by SDS - PAGE
form :
Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 5mM DTT, 20% glycerol, 200mM NaCl
concentration :
0.5mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Immunology
products description :
FAB3C belongs to the FAM3 family and contains a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. Fam3c may be a downstream target gene for the Nkx5.1 transcription factor, and may thus be involved in cell differentiation and proliferation during inner ear embryogenesis. Also, it may be involved in retinal laminar formation and promotes epithelial to mesenchymal transition. Recombinant human FAM3C, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Zhu Y, et al. (2002) Genomics 80 (2): 144-50. Pilipenko VV, et al. (2004) Gene. 335:159-68.
ncbi gb acc num :
NM_014888.2
ncbi mol weight :
24.5kD (224aa), confirmed by MALDI-TOF
ncbi summary :
This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010]
uniprot summary :
FAM3C: May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. Belongs to the FAM3 family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 7q31. Cellular Component: Golgi apparatus; cytoplasmic membrane-bound vesicle; extracellular region. Molecular Function: cytokine activity. Biological Process: multicellular organismal development