product summary
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company name :
MyBioSource
product type :
protein
product name :
ARPC5, 1-151aa, Human, His tag, E Coli
catalog :
MBS204029
quantity :
0.1 mg
price :
310 USD
more info or order :
product information
catalog number :
MBS204029
products type :
Recombinant Protein
products full name :
ARPC5, 1-151aa, Human, His tag, E Coli
products short name :
ARPC5
products name syn :
Actin related protein 2/3 complex; subunit 5; p16-ARC; ARC16
other names :
actin-related protein 2/3 complex subunit 5 isoform 1; Actin-related protein 2/3 complex subunit 5; actin-related protein 2/3 complex subunit 5; Arp2/3 protein complex subunit p16; arp2/3 complex 16 kDa subunit; actin related protein 2/3 complex, subunit 5, 16kDa; Arp2/3 complex 16 kDa subunit; p16-ARC
products gene name :
ARPC5
other gene names :
ARPC5; ARPC5; ARC16; p16-Arc; dJ127C7.3; ARC16; p16-ARC
uniprot entry name :
ARPC5_HUMAN
sequence length :
151
sequence :
MGSSHHHHHH SSGLVPRGSH MSKNTVSSAR FRKVDVDEYD ENKFVDEEDG GDGQAGPDEG EVDSCLRQGN MTAALQAALK NPPINTKSQA VKDRAGSIVL KVLISFKAND IEKAVQSLDK NGVDLLMKYI YKGFESPSDN SSAMLLQWHE KALAAGGVGS IVRVLTARKT V
purity :
> 90% by SDS - PAGE
form :
Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 50% glycerol, 0.1M NaCl
concentration :
0.5 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Cytoskeleton
products description :
p16-ARC, also known as ARPC5, is a 151 amino acid subunit of the Arp2/3 complex. Thought to play a role in maintaining the integrity of Arp2/3, ARPC5 is a substrate for MAPKAPK-2 which, through phosphorylation of ARPC5, may participate in Arp2/3 regulatory functions and remodeling of the Actin cytoskeleton. Two isoforms of ARPC5 exist due to alternative splicing events. Recombinant human ARPC5 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Machesky L M., et al. (1998) Biochem J. 328:105-112. Welch M D., et al. (1997) J Cell Biol. 138:375-384.
ncbi gi num :
5031593
ncbi acc num :
NP_005708
ncbi gb acc num :
NM_005717.3
ncbi mol weight :
18.4 kDa (171aa), confirmed by MALDI-TOF
ncbi pathways :
Axon Guidance Pathway (105688); B Cell Receptor Signaling Pathway (198909); Bacterial Invasion Of Epithelial Cells Pathway (149807); Bacterial Invasion Of Epithelial Cells Pathway (148661); CDC42 Signaling Events Pathway (137994); Developmental Biology Pathway (477129); EPH-Ephrin Signaling Pathway (1127691); EPHB-mediated Forward Signaling Pathway (1127693); ErbB1 Downstream Signaling Pathway (138057); Fc Gamma R-mediated Phagocytosis Pathway (114228)
ncbi summary :
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
uniprot summary :
ARPC5: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Belongs to the ARPC5 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Cytoskeletal. Chromosomal Location of Human Ortholog: 1q25.3. Cellular Component: Arp2/3 protein complex; cell projection; focal adhesion; cytoplasm; cytosol; actin cytoskeleton. Molecular Function: actin filament binding; protein binding; structural constituent of cytoskeleton. Biological Process: axon guidance; ephrin receptor signaling pathway; innate immune response; cell motility; actin cytoskeleton organization and biogenesis
size1 :
0.1 mg
price1 :
310 USD
size2 :
0.5 mg
price2 :
720
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
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