protein

c-Jun, 1-241aa, Human, His tag, E Coli

MBS204023

0.01 mg

310 USD

Recombinant Protein

c-Jun, 1-241aa, Human, His tag, E Coli

c-Jun

Transcription factor AP-1; AP-1; AP1; c-Jun; jun proto-oncogene

transcription factor AP-1; Transcription factor AP-1; transcription factor AP-1; Jun activation domain binding protein; activator protein 1; enhancer-binding protein AP1; jun oncogene; p39; proto-oncogene c-Jun; v-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog; jun proto-oncogene; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39

c-Jun

JUN; JUN; AP1; AP-1; c-Jun; AP1

JUN_HUMAN

331

MGSSHHHHHH SSGLVPRGSH MTAKMETTFY DDALNASFLP SESGPYGYSN PKILKQSMTL NLADPVGSLK PHLRAKNSDL LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE LHSQNTLPSV TSAAQPVNGA GMVAPAVASV AGGSGSGGFS ASLHSEPPVY ANLSNFNPGA LSSGGGAPSY GAAGLAFPAQ PQQQQQPPHH LPQQMPVQHP RLQALKEEPQ TVPEMPGETP P

> 90 % by SDS - PAGE

Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl.

0.25 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Cancer

The human protooncogene c-Jun is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. c-Jun and c-Fos form a complex in the nucleus. AP1 is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21, p19 and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. Recombinant human c-Jun protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Bohmann D., et al. (1987) Science. 238(4832):1386-92. Bannister AJ., et al. (1993) Nucleic Acids Res. 21(5):1289-95.

4758616

NP_002219

NM_002228.3

27.3 kDa (261 aa) confirmed by MALDI-TOF

AGE/RAGE Pathway (698754); ATF-2 Transcription Factor Network Pathway (138006); Activated TLR4 Signalling Pathway (106400); Activation Of The AP-1 Family Of Transcription Factors Pathway (160139); AhR Pathway (755436); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Androgen Receptor Signaling Pathway (198806); Apoptosis Pathway (198797); Apoptosis Modulation And Signaling Pathway (198822)

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]

Jun: the protooncogene c-Jun is a component of the transcription factor AP-1, which binds and activates transcription at TRE/AP-1 elements. The Jun Kinases (JNKs) binds to the N-terminal region of c-Jun and phosphorylate it in response to extracellular signals including growth factors, cytokines and stress, regulating its transcriptional activity. Protein type: Oncoprotein; Transcription factor. Chromosomal Location of Human Ortholog: 1p32-p31. Cellular Component: nucleoplasm; nuclear chromosome; transcription factor complex; transcriptional repressor complex; cytosol; nucleus. Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; enzyme binding; DNA binding; transcription coactivator activity; double-stranded DNA binding; transcription factor activity; transcription factor binding. Biological Process: positive regulation of monocyte differentiation; transcription from RNA polymerase II promoter; circadian rhythm; response to cAMP; regulation of cell cycle; positive regulation of transcription, DNA-dependent; positive regulation of smooth muscle cell proliferation; stress-activated MAPK cascade; microglial cell activation; response to lipopolysaccharide; SMAD protein nuclear translocation; toll-like receptor 3 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; negative regulation of cell proliferation; positive regulation of fibroblast proliferation; response to radiation; regulation of transcription factor activity; positive regulation of neuron apoptosis; transforming growth factor beta receptor signaling pathway; negative regulation of protein amino acid autophosphorylation; negative regulation of neuron apoptosis; angiogenesis; toll-like receptor 4 signaling pathway; aging; response to drug; release of cytochrome c from mitochondria; monocyte differentiation; leading edge cell differentiation; MyD88-independent toll-like receptor signaling pathway; axon regeneration; learning; liver development; negative regulation of DNA binding; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; membrane depolarization; cellular response to potassium ion starvation; response to hydrogen peroxide; response to mechanical stimulus; response to cytokine stimulus; toll-like receptor signaling pathway; innate immune response; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; negative regulation of transcription, DNA-dependent; positive regulation of DNA replication

0.01 mg

310 USD

0.05 mg

720