antibody

APC-Linked Monoclonal Antibody to Transferrin Receptor 2 (TFR2)

MBS2040225

0.1 mg

230 USD

monoclonal

mouse

APC

western blot, immunohistochemistry, immunocytochemistry

Antibody

APC-Linked Monoclonal Antibody to Transferrin Receptor 2 (TFR2)

[Transferrin Receptor 2 (TFR2)]

[transferrin receptor protein 2 isoform 2; Transferrin receptor protein 2; transferrin receptor protein 2; transferrin receptor 2]

[TFR2]

[TFR2; TFR2; HFE3; TFRC2; TfR2]

Monoclonal

Mouse

Protein A/G Affinity Chromatography.

Supplied as a solution form in 0.01 PBS, pH 7.4, containing 0.05% Proclin-300,50% glycerol.

0.39 mg/mL

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use . Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

WB, IHC, ICC, IF

Western blotting: 0.5- ug/mL; 1:200-800. Immunohistochemistry: 5-20 ug/mL; 1:20-80. Immunocytochemistry: 5-20 ug/mL; 1:20-80 . Optimal working dilutions must be determined by end user.

Organism Species: Homo Sapiens(Human). Source: Monoclonal antibody preparation. Label: APC. Traits: Liquid. Immunogen: Recombinant TFR2 (Leu4~Leu87) expressed in E.coli.

332309171

NP_001193784.1

NM_001206855.1

Q9UP52

Iron Metabolism In Placenta Pathway (672461)

This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

TFR2: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Defects in TFR2 are a cause of hemochromatosis type 3 (HFE3). HFE3 is a disorder of iron hemostasis resulting in iron overload and has a phenotype indistinguishable from that of hereditary hemochromatosis (HH). HH is characterized by abnormal intestinal iron absorption and progressive increase of total body iron, which results in midlife in clinical complications including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy, and susceptibility to liver cancer. Since the disease complications can be effectively prevented by regular phlebotomies, early diagnosis is most important to provide a normal life expectancy to the affected subjects. Belongs to the peptidase M28 family. M28B subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 7q22.1. Cellular Component: cytoplasmic vesicle; external side of plasma membrane; integral to plasma membrane. Molecular Function: glycoprotein binding; protein binding; transferrin receptor activity. Biological Process: cellular iron ion homeostasis; iron ion homeostasis; positive regulation of endocytosis; positive regulation of transcription from RNA polymerase II promoter; receptor-mediated endocytosis; response to iron ion; transferrin transport. Disease: Hemochromatosis, Type 3

0.1 mg

230 USD

0.2 mg

305

1 mg

725