product summary
Loading...
company name :
MyBioSource
product type :
protein
product name :
Human, His-tagged, Recombinant, E Coli; SEPSECS, 1-501aa
catalog :
MBS204016
quantity :
0.1 mg
price :
310 USD
more info or order :
product information
catalog number :
MBS204016
products type :
Recombinant Protein
products full name :
Human, His-tagged, Recombinant, E Coli; SEPSECS, 1-501aa
products short name :
SEPSECS
products name syn :
O-phosphoseryl-tRNA(Sec) selenium transferase; O-phosphoseryl-tRNA(Sec) selenium transferase
other names :
O-phosphoseryl-tRNA(Sec) selenium transferase; O-phosphoseryl-tRNA(Sec) selenium transferase; O-phosphoseryl-tRNA(Sec) selenium transferase; O-phosphoseryl-tRNA(Sec) selenium transferase; SLA-p35; SLA/LP autoantigen; UGA suppressor tRNA-associated protein; liver-pancreas antigen; soluble liver antigen; soluble liver antigen/liver pancreas antigen; tRNA(Ser/Sec)-associated antigenic protein; Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase; Liver-pancreas antigen; LP; SLA-p35; SLA/LP autoantigen; Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep-tRNA:Sec-tRNA synthase; SepSecS; Soluble liver antigen; SLA; UGA suppressor tRNA-associated protein; tRNA(Ser/Sec)-associated antigenic protein
products gene name :
SEPSECS
other gene names :
SEPSECS; SEPSECS; LP; SLA; PCH2D; SLA/LP; TRNP48; LP; Sec synthase; SepSecS; SLA
uniprot entry name :
SPCS_HUMAN
sequence length :
501
sequence :
MGSSHHHHHH SSGLVPRGSH MNRESFAAGE RLVSPAYVRQ GCEARRSHEH LIRLLLEKGK CPENGWDEST LELFLHELAI MDSNNFLGNC GVGEREGRVA SALVARRHYR FIHGIGRSGD ISAVQPKAAG SSLLNKITNS LVLDIIKLAG VHTVANCFVV PMATGMSLTL CFLTLRHKRP KAKYIIWPRI DQKSCFKSMI TAGFEPVVIE NVLEGDELRT DLKAVEAKVQ ELGPDCILCI HSTTSCFAPR VPDRLEELAV ICANYDIPHI VNNAYGVQSS KCMHLIQQGA RVGRIDAFVQ SLDKNFMVPV GGAIIAGFND SFIQEISKMY PGRASASPSL DVLITLLSLG SNGYKKLLKE RKEMFSYLSN QIKKLSEAYN ERLLHTPHNP ISLAMTLKTL DEHRDKAVTQ LGSMLFTRQV SGARVVPLGS MQTVSGYTFR GFMSHTNNYP CAYLNAASAI GMKMQDVDLF IKRLDRCLKA VRKERSKESD DNYDKTEDVD IEEMALKLDN VLLDTYQDAS S
purity :
> 90% by SDS - PAGE
form :
Liquid. In Phosphate Buffer Saline (pH 7.4) containing 20% glycerol, 1mM DTT.
concentration :
0.5mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Enzymes & Proteases
products description :
SEPSECS, also known as SLA/LP autoantigen, catalyzes the final step of sec synthesis by converting O-phosphoseryl-tRNA(sec) to selenocysteinyl-tRNA(sec) using selenophosphate as the selenium donor. Also, this protein is considered a specific marker of autoimmune hepatitis. Recombinant human SEPSECS protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Palioura S., et al. (2009) Science. 325(5938):321-5. Yuan J.,et al. (2006) Proc. Natl. Acad. Sci. u.S.A. 103:18923-18927
ncbi gi num :
267844904
ncbi acc num :
NP_058651
ncbi gb acc num :
NM_016955.3
ncbi mol weight :
57.9kDa (521aa), confirmed by MALDI-TOF
ncbi pathways :
Aminoacyl-tRNA Biosynthesis Pathway (83030); Aminoacyl-tRNA Biosynthesis Pathway (424); Selenium Metabolism And Selenoproteins Pathway (198846); Selenocompound Metabolism Pathway (82969); Selenocompound Metabolism Pathway (338)
ncbi summary :
The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein encoded by this gene catalyzes the third step in the process, the conversion of O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).[provided by RefSeq, Mar 2011]
uniprot summary :
SLA/LP: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. Defects in SEPSECS are the cause of pontocerebellar hypoplasia type 2D (PCH2D). PCH2D is a disorder characterized by postnatal onset of progressive atrophy of the cerebrum and cerebellum, microcephaly, profound mental retardation, spasticity, and variable seizures. Belongs to the SepSecS family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 2.9.1.2; RNA-binding; Transferase. Chromosomal Location of Human Ortholog: 4p15.2. Cellular Component: cytoplasm; nucleus. Molecular Function: protein binding; transferase activity, transferring selenium-containing groups; tRNA binding; pyridoxal phosphate binding. Biological Process: selenocysteine incorporation. Disease: Pontocerebellar Hypoplasia, Type 2d
size1 :
0.1 mg
price1 :
310 USD
size2 :
0.5 mg
price2 :
720
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!