catalog number :
MBS203944
products type :
Recombinant Protein
products full name :
LCN2, 21-198aa, Human, His tag, E Coli
products short name :
LCN2
products name syn :
Neutrophil gelatinase-associated lipocalin; Lipocalin-2; MSFI; NGAL; Oncogene 24p3; p25; HNL
other names :
neutrophil gelatinase-associated lipocalin; Neutrophil gelatinase-associated lipocalin; neutrophil gelatinase-associated lipocalin; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; lipocalin-2; migration-stimulating factor inhibitor; oncogene 24p3; p25; siderocalin LCN2; lipocalin 2; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; Siderocalin LCN2; p25
products gene name :
LCN2
other gene names :
LCN2; LCN2; 24p3; MSFI; NGAL; HNL; NGAL; NGAL
uniprot entry name :
NGAL_HUMAN
sequence :
MGSSHHHHHH SSGLVPRGSH MQDSTSDLIP APPLSKVPLQ QNFQDNQFQG KWYVVGLAGN AILREDKDPQ KMYATIYELK EDKSYNVTSV LFRKKKCDYW IRTFVPGCQP GEFTLGNIKS YPGLTSYLVR VVSTNYNQHA MVFFKKVSQN REYFKITLYG RTKELTSELK ENFIRFSKSL GLPENHIVFP VPIDQCIDG
purity :
> 90% by SDS - PAGE
form :
Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 1mM DTT, 50mM NaCl
concentration :
1mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Immunology
products description :
Neutrophil gelatinase-associated lipocalin (NGAL), also known as LCN2, belongs to the calycin superfamily and Lipocalin family. LCN2 is an iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. The binding of LCN2 to bacterial siderophores is important in the innate immune response to bacterial infection. Also LCN2 functions as a growth factor. LCN2 is strongly upregulated during inflammation and is upregulated by interleukin 1 (but not TNF alpha) in humans. Recombinant human LCN2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Flo TH., et al. (2004) Nature 432 (7019): 917-21. Yang J., et al. (2002) Mol. Cell 10:1045-1056
ncbi gb acc num :
NM_005564.3
ncbi mol weight :
22.8kDa (199aa), confirmed by MALDI-TOF
ncbi pathways :
Iron Uptake And Transport Pathway 187191!!Orphan Transporters Pathway 1127546!!Transmembrane Transport Of Small Molecules Pathway 106572