protein

BATF, 1-125aa, Human, His tag, E Coli

MBS203924

0.1 mg

310 USD

Recombinant Protein

BATF, 1-125aa, Human, His tag, E Coli

BATF

Basic leucine zipper transcriptional factor ATF-like; B-ATF; BATF1; SFA-2; SFA2

basic leucine zipper transcriptional factor ATF-like; Basic leucine zipper transcriptional factor ATF-like; basic leucine zipper transcriptional factor ATF-like; B-cell-activating transcription factor; SF-HT-activated gene 2 protein; activating transcription factor B; basic leucine zipper transcription factor, ATF-like; B-cell-activating transcription factor; B-ATF; SF-HT-activated gene 2 protein; SFA-2

BATF

BATF; BATF; SFA2; B-ATF; BATF1; SFA-2; B-ATF; SFA-2

BATF_HUMAN

125

MGSSHHHHHH SSGLVPRGSH MPHSSDSSDS SFSRSPPPGK QDSSDDVRRV QRREKNRIAA QKSRQRQTQK ADTLHLESED LEKQNAALRK EIKQLTEELK YFTSVLNSHE PLCSVLAAST PSPPEVVYSA HAFHQPHVSS PRFQP

> 90% by SDS - PAGE

Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl, 2mM DTT, 40% glycerol

1 mg/ml (determined by BCA assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Transcription & Translation

BATF, also known as SFA2, is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. BATF is strongly expressed in mature T and B lymphocytes, and is up-regulated after transformation by human T-cell leukemia virus type I. BATF functions as a tissue-specific modulator of the AP-1 transcription complex in human cells. BATF also associates with IFP35, a leucine zipper protein that translocates to the nucleus following IFN treatment. Recombinant human BATF protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Quigley M., et al. (2010) Nat Med. 16(10):1147-51. Betz BC., et al. (2010) J Exp Med. 207(5):933-42.

5453563

NP_006390

NM_006399.3

16.2 kDa (145aa), confirmed by MALDI-TOF

The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008]

BATF: a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. Functions as a negative regulator of AP-1 mediated transcription by binding to Jun proteins. Jun/B-ATF heterodimers bind DNA preferentially at the 12-O-tetradecanoylphorbol-13- acetate response element (TRE) and weaker at the cAMP responsive region (CRE), but are transcriptionally inert. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 14q24.3. Cellular Component: cytoplasm; nucleus. Molecular Function: protein binding; sequence-specific DNA binding; transcription factor activity. Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; DNA damage response, signal transduction by p53 class mediator; isotype switching; cytokine production; lymphoid progenitor cell differentiation; myeloid dendritic cell differentiation; T-helper 2 cell differentiation; defense response to protozoan; response to DNA damage stimulus

0.1 mg

310 USD

0.5 mg

720