protein

PDIA6, 20-440aa, Human, His tag, E Coli

MBS203910

0.1 mg

310 USD

Recombinant Protein

PDIA6, 20-440aa, Human, His tag, E Coli

PDIA6

Protein disulfide-isomerase A6; ERP5; P5; TXNDC7

protein disulfide-isomerase A6 isoform d; Protein disulfide-isomerase A6; protein disulfide-isomerase A6; ER protein 5; endoplasmic reticulum protein 5; protein disulfide isomerase P5; protein disulfide isomerase-associated 6; protein disulfide isomerase-related protein; thioredoxin domain containing 7 (protein disulfide isomerase); thioredoxin domain-containing protein 7; protein disulfide isomerase family A, member 6; Endoplasmic reticulum protein 5; ER protein 5; ERp5; Protein disulfide isomerase P5; Thioredoxin domain-containing protein 7

PDIA6

PDIA6; PDIA6; P5; ERP5; TXNDC7; ERP5; P5; TXNDC7; ER protein 5; ERp5

PDIA6_HUMAN

440

MGSSHHHHHH SSGLVPRGSH MLYSSSDDVI ELTPSNFNRE VIQSDSLWLV EFYAPWCGHC QRLTPEWKKA ATALKDVVKV GAVDADKHHS LGGQYGVQGF PTIKIFGSNK NRPEDYQGGR TGEAIVDAAL SALRQLVKDR LGGRSGGYSS GKQGRSDSSS KKDVIELTDD SFDKNVLDSE DVWMVEFYAP WCGHCKNLEP EWAAAASEVK EQTKGKVKLA AVDATVNQVL ASRYGIRGFP TIKIFQKGES PVDYDGGRTR SDIVSRALDL FSDNAPPPEL LEIINEDIAK RTCEEHQLCV VAVLPHILDT GAAGRNSYLE VLLKLADKYK KKMWGWLWTE AGAQSELETA LGIGGFGYPA MAAINARKMK FALLKGSFSE QGINEFLREL SFGRGSTAPV GGGAFPTIVE REPWDGRDGE LPVEDDIDLS DVELDDLGKD EL

> 90% by SDS - PAGE

Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 2mM DTT, 50mM NaCl

1mg/ml (determined by Bradford)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Heat Shock Proteins

PDIA6 is a member of the protein disulfide isomerase (PDI). PDI is an enzyme in the endoplasmic reticulum in eukaryotes or periplasmic space of prokaryotes that catalyzes the formation and breakage of disulfide bonds between cysteine residues within proteins as they fold. PDIA6 function as a chaperone that inhibits aggregation of misfolded proteins. It plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. Recombinant human PDIA6 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Jordan P.A., et al. (2005) Blood 105:1500-1507. Kikuchi M., et al. (2002) J. Biochem. 132:451-455.

5031973

NP_005733

NM_005742.3

48.5kDa (442aa) confirmed by MALDI-TOF

IRE1alpha Activates Chaperones Pathway (105906); Metabolism Of Proteins Pathway (106230); Protein Processing In Endoplasmic Reticulum Pathway (167325); Protein Processing In Endoplasmic Reticulum Pathway (167190); Unfolded Protein Response (UPR) Pathway (105904); XBP1(S) Activates Chaperone Genes Pathway (530771)

Protein disulfide isomerases (EC 5.3.4.1), such as PDIA6, are endoplasmic reticulum (ER) resident proteins that catalyze formation, reduction, and isomerization of disulfide bonds in proteins and are thought to play a role in folding of disulfide-bonded proteins (Hayano and Kikuchi, 1995 [PubMed 7590364]).[supplied by OMIM, Mar 2008]

PDIA6: May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. Belongs to the protein disulfide isomerase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 5.3.4.1; Isomerase. Chromosomal Location of Human Ortholog: 2p25.1. Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; endoplasmic reticulum lumen; melanosome; plasma membrane; ER-Golgi intermediate compartment. Molecular Function: protein binding; protein disulfide isomerase activity. Biological Process: unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; protein folding; cell redox homeostasis; unfolded protein response; apoptotic cell clearance

0.1 mg

310 USD

0.5 mg

720