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company name :
MyBioSource
product type :
protein
product name :
IMPA2, 1-288aa, Human, His tag, E Coli
catalog :
MBS203826
quantity :
0.05 mg
price :
310 USD
more info or order :
product information
catalog number :
MBS203826
products type :
Recombinant Protein
products full name :
IMPA2, 1-288aa, Human, His tag, E Coli
products short name :
IMPA2
products name syn :
Inositol monophosphatase 2; Inositol(myo)-1(or 4)-monophosphatase 2
other names :
inositol monophosphatase 2; Inositol monophosphatase 2; inositol monophosphatase 2; IMP 2; IMPase 2; inosine monophosphatase 2; inositol monophosphatase 2 variant 1; inositol monophosphatase 2 variant 2; myo-inositol monophosphatase A2; inositol(myo)-1(or 4)-monophosphatase 2; Inositol-1(or 4)-monophosphatase 2; Myo-inositol monophosphatase A2
products gene name :
IMPA2
other gene names :
IMPA2; IMPA2; IMP.18P; IMP 2; IMPase 2
uniprot entry name :
IMPA2_HUMAN
sequence length :
288
sequence :
MGSSHHHHHH SSGLVPRGSH MKPSGEDQAA LAAGPWEECF QAAVQLALRA GQIIRKALTE EKRVSTKTSA ADLVTETDHL VEDLIISELR ERFPSHRFIA EEAAASGAKC VLTHSPTWII DPIDGTCNFV HRFPTVAVSI GFAVRQELEF GVIYHCTEER LYTGRRGRGA FCNGQRLRVS GETDLSKALV LTEIGPKRDP ATLKLFLSNM ERLLHAKAHG VRVIGSSTLA LCHLASGAAD AYYQFGLHCW DLAAATVIIR EAGGIVIDTS GGPLDLMACR VVAASTREMA MLIAQALQTI NYGRDDEK
purity :
> 95% by SDS - PAGE
form :
Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 2mM DTT.
concentration :
0.25 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Metabolism
products description :
IMPA2 belongs to the inositol monophosphatase family. This protein can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. IMPA2 has been implicated as the pharmacological target for lithium Li(+) action in brain. IMPA2 is thought to play a role in schizophrenia and bipolar disorder. Recombinant human IMPA2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Sjoholt G., et al. (2000) Mol Psychiatry. 5(2):172-80. Yoshikawa T., et al. (1997) Mol Psychiatry. 2(5):393-7.
ncbi gi num :
7657236
ncbi acc num :
NP_055029
ncbi gb acc num :
NM_014214.2
ncbi mol weight :
33.5 kDa (308aa), confirmed by MALDI-TOF
ncbi pathways :
D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway (545327); D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway (138942); Inositol Phosphate Metabolism Pathway (82987); Inositol Phosphate Metabolism Pathway (730320); Inositol Phosphate Metabolism Pathway (362); Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 = Ins(1,3,4)P3 = Myo-inositol Pathway (413401); Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 = Ins(1,3,4)P3 = Myo-inositol Pathway (468324); Metabolic Pathways (132956); Metabolism Pathway (477135); Phosphatidylinositol Signaling System Pathway (83052)
ncbi summary :
This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]
uniprot summary :
IMPA2: Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2 - AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain. Belongs to the inositol monophosphatase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.25; Phosphatase (non-protein). Chromosomal Location of Human Ortholog: 18p11.2. Cellular Component: cytoplasm; cytosol. Molecular Function: protein homodimerization activity; metal ion binding; inositol-1(or 4)-monophosphatase activity. Biological Process: inositol phosphate metabolic process; phosphoinositide phosphorylation; inositol phosphate dephosphorylation; inositol biosynthetic process; signal transduction; phosphate metabolic process
size1 :
0.05 mg
price1 :
310 USD
size2 :
0.25 mg
price2 :
720
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
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