protein

ANXA11, 1-505aa, Human, His tag, E Coli

MBS203822

0.1 mg

375 USD

Recombinant Protein

ANXA11, 1-505aa, Human, His tag, E Coli

ANXA11

Annexin A11; ANX11; CAP50; Annexin-11; Annexin XI

annexin A11 isoform 1; Annexin A11; annexin A11; 56 kDa autoantigen; CAP-50; annexin XI; annexin-11; autoantigen, 56-kD; calcyclin-associated annexin 50; annexin A11; 56 kDa autoantigen; Annexin XI; Annexin-11; Calcyclin-associated annexin 50; CAP-50

ANXA11

ANXA11; ANXA11; ANX11; CAP50; ANX11; CAP-50

ANX11_HUMAN

505

MGSSHHHHHH SSGLVPRGSH MSYPGYPPPP GGYPPAAPGG GPWGGAAYPP PPSMPPIGLD NVATYAGQFN QDYLSGMAAN MSGTFGGANM PNLYPGAPGA GYPPVPPGGF GQPPSAQQPV PPYGMYPPPG GNPPSRMPSY PPYPGAPVPG QPMPPPGQQP PGAYPGQPPV TYPGQPPVPL PGQQQPVPSY PGYPGSGTVT PAVPPTQFGS RGTITDAPGF DPLRDAEVLR KAMKGFGTDE QAIIDCLGSR SNKQRQQILL SFKTAYGKDL IKDLKSELSG NFEKTILALM KTPVLFDIYE IKEAIKGVGT DEACLIEILA SRSNEHIREL NRAYKAEFKK TLEEAIRSDT SGHFQRLLIS LSQGNRDEST NVDMSLAQRD AQELYAAGEN RLGTDESKFN AVLCSRSRAH LVAVFNEYQR MTGRDIEKSI CREMSGDLEE GMLAVVKCLK NTPAFFAERL NKAMRGAGTK DRTLIRIMVS RSETDLLDIR SEYKRMYGKS LYHDISGDTS GDYRKILLKI CGGND

> 95% by SDS - PAGE

Liquid. In PBS containing 20% glycerol, 2mM DTT, 100mM NaCl

0.25mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Signal Transduction

ANXA11 (Annexin A11) is a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-binding sites. ANXA11 binds specifically to calcyclin in a calcium-dependent manner. And it required for midbody formation and completion of the terminal phase of cytokinesis. This protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Recombinant ANXA11 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Tomas A., et al. (2004) J. Cell Biol. 165:813-822 . Satoh., et al. (2002) Biochem. Biophys. Res. Commun. 291 (5): 1166-72.

4557317

NP_001148

NM_001157.2

56.6kDa (525aa) confirmed by MALDI-TOF

This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, May 2013]

ANXA11: a calcium/phospholipid-binding protein found throughout the nucleoplasm at interphase and at the mitotic phase is concentrated at the loop-like structure around the mitotic apparatus. May interact with calcyclin (S100A6) in vivo. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion. Protein type: Motility/polarity/chemotaxis; Calcium-binding; Lipid-binding; Nuclear envelope. Chromosomal Location of Human Ortholog: 10q23. Cellular Component: nucleoplasm; azurophil granule; specific granule; membrane; cytoplasm; melanosome; spindle; nuclear envelope; phagocytic vesicle; midbody. Molecular Function: protein binding; phosphatidylethanolamine binding; calcium-dependent phospholipid binding; calcium ion binding; calcium-dependent protein binding. Biological Process: response to calcium ion; phagocytosis

0.1 mg

375 USD

0.5 mg

925