RAC3, 1-189aa, Human, E Coli | MyBioSource MBS203763 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

RAC3, 1-189aa, Human, E Coli

catalog :

MBS203763

quantity :

0.1 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS203763

products type :

Recombinant Protein

products full name :

RAC3, 1-189aa, Human, E Coli

products short name :

RAC3

products name syn :

ras-related C3 botulinum toxin substrate 3; p21-Rac3; Rac1B; RAS related C3 botulinum substrate 3; Ras related C3 botulinum toxin substrate 3; rho family small GTP binding protein Rac3; Rho family small GTP binding protein Rac3; RP23-84C12.18

other names :

ras-related C3 botulinum toxin substrate 3; Ras-related C3 botulinum toxin substrate 3; ras-related C3 botulinum toxin substrate 3; p21-Rac3; rho family, small GTP binding protein Rac3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3); p21-Rac3

products gene name :

RAC3

other gene names :

RAC3; RAC3

uniprot entry name :

RAC3_HUMAN

sequence length :

192

sequence :

MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPHTPI LLVGTKLDLR DDKDTIERLR DKKLAPITYP QGLAMAREIG SVKYLECSAL TQRGLKTVFD EAIRAVLCPP PVKKPGKKC

purity :

> 95% by SDS - PAGE

form :

Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 2mM DTT, 200mM NaCl, 0.1mM PMSF, 1mM EDTA

concentration :

0.5mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human

other info2 :

Expression System: E Coli

products categories :

Signal Transduction

products description :

RAC3 is a member of the Rac subfamily of the Rho small G proteins. This protein is a small (~21 kDa) monomeric GTP-binding protein, and is an important component of intracellular signalling pathway, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Recombinant human RAC3 protein was expressed in E.coli and purified by using conventional chromatography techniques.

products references :

De Langhe S., et al. (2002) Int. J. Mol. Med. 9:451-459. Haataja L, et al. (1997) J. Biol. Chem. 272 (33): 20384-88.

ncbi gi num :

4826962

ncbi acc num :

NP_005043

ncbi gb acc num :

NM_005052.2

ncbi mol weight :

21kDa (189aa), confirmed by MALDI-TOF

ncbi pathways :

Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Axon Guidance Pathway (83065); Axon Guidance Pathway (476); B Cell Receptor Signaling Pathway (83081); B Cell Receptor Signaling Pathway (492); Choline Metabolism In Cancer Pathway (1059539); Choline Metabolism In Cancer Pathway (1084232); Colorectal Cancer Pathway (83106); Colorectal Cancer Pathway (518)

ncbi summary :

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. [provided by RefSeq, Jul 2008]

uniprot summary :

RAC3: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D. Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation. Highest levels in brain, also detected in heart, placenta and pancreas. Belongs to the small GTPase superfamily. Rho family. Protein type: Motility/polarity/chemotaxis; G protein, monomeric; G protein, monomeric, Rho; G protein. Chromosomal Location of Human Ortholog: 17q25.3. Cellular Component: filamentous actin; neuron projection; growth cone; cell soma; perinuclear region of cytoplasm; lamellipodium; plasma membrane; endomembrane system; cytosol. Molecular Function: GTPase activity; protein binding; GTP binding; calcium-dependent protein binding. Biological Process: regulation of small GTPase mediated signal transduction; metabolic process; small GTPase mediated signal transduction; positive regulation of cell adhesion mediated by integrin; cell projection biogenesis; actin cytoskeleton organization and biogenesis; neuromuscular process controlling balance; neurite development

size1 :

0.1 mg

price1 :

310 USD

size2 :

0.5 mg

price2 :

720

more info or order :

MyBioSource product webpage