product summary
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company name :
MyBioSource
product type :
protein
product name :
BAG2, 1-211aa, Human, His tag, E Coli
catalog :
MBS203762
quantity :
0.1 mg
price :
310 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS203762
products type :
Recombinant Protein
products full name :
BAG2, 1-211aa, Human, His tag, E Coli
products short name :
BAG2
products name syn :
BCL2-associated athanogene 2; BAG-2
other names :
BAG family molecular chaperone regulator 2; BAG family molecular chaperone regulator 2; BAG family molecular chaperone regulator 2; BAG-family molecular chaperone regulator-2; bcl-2-associated athanogene 2; dJ417I1.2 (BAG-family molecular chaperone regulator 2); BCL2-associated athanogene 2; Bcl-2-associated athanogene 2
products gene name :
BAG2
other gene names :
BAG2; BAG2; BAG-2; dJ417I1.2; BAG-2
uniprot entry name :
BAG2_HUMAN
sequence length :
211
sequence :
MGSSHHHHHH SSGLVPRGSH MAQAKINAKA NEGRFCRSSS MADRSSRLLE SLDQLELRVE ALREAATAVE QEKEILLEMI HSIQNSQDMR QISDGEREEL NLTANRLMGR TLTVEVSVET IRNPQQQESL KHATRIIDEV VNKFLDDLGN AKSHLMSLYS ACSSEVPHGP VDQKFQSIVI GCALEDQKKI KRRLETLLRN IENSDKAIKL LEHSKGAGSK TLQQNAESRF N
purity :
> 95% by SDS - PAGE
form :
Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 0.1M NaCl
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Heat Shock Proteins
products description :
BCL2-associated athanogene 2, also known as BAG2, is a member of the Bag family of proteins. BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain. BAG2 is a major component of the HSC 70/CHIP chaperone-dependent ubiquitin ligase complex and acts to disrupt CHIP-mediated ubiquitylation. Recombinant human BAG2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Takayama S., et al. (1999) J Biol Chem. 274:781-786. Arndt V., et al. (2005) CHIP Mol Biol Cell. 16:5891-5900.
ncbi gi num :
4757834
ncbi acc num :
NP_004273
ncbi gb acc num :
NM_004282.3
ncbi mol weight :
25.9 kDa (231aa) confirmed by MALDI-TOF
ncbi pathways :
Protein Processing In Endoplasmic Reticulum Pathway 167325!!Protein Processing In Endoplasmic Reticulum Pathway 167190
ncbi summary :
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
size :
0.1 mg
price :
310 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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