DNAJB11, 23-358aa, Human, His tag, E Coli | MyBioSource MBS203750 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

DNAJB11, 23-358aa, Human, His tag, E Coli

catalog :

MBS203750

quantity :

0.01 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS203750

products type :

Recombinant Protein

products full name :

DNAJB11, 23-358aa, Human, His tag, E Coli

products short name :

DNAJB11

products name syn :

DnaJ homolog subfamily B member 11; ABBP-2; ABBP2; DJ9; EDJ; ERdj3; ERj3; hDj9; HEDJ; PRO1080; uNQ537

other names :

dnaJ homolog subfamily B member 11; DnaJ homolog subfamily B member 11; dnaJ homolog subfamily B member 11; APOBEC1-binding protein 2; DnaJ protein 9; ER-associated DNAJ protein 3; ER-associated Hsp40 co-chaperone; ER-resident protein ERdj3; PWP1-interacting protein 4; endoplasmic reticulum DNA J domain-containing protein 3; DnaJ (Hsp40) homolog, subfamily B, member 11; APOBEC1-binding protein 2; ABBP-2; DnaJ protein homolog 9; ER-associated DNAJ; ER-associated Hsp40 co-chaperone; Endoplasmic reticulum DNA J domain-containing protein 3; ER-resident protein ERdj3; ERdj3; ERj3p; HEDJ; Human DnaJ protein 9; hDj-9; PWP1-interacting protein 4

products gene name :

DNAJB11

other gene names :

DNAJB11; DNAJB11; DJ9; EDJ; Dj-9; ERj3; ABBP2; ERdj3; ERj3p; ABBP-2; UNQ537; PRO1080; EDJ; ERJ3; HDJ9; ABBP-2; ER-resident protein ERdj3; ERdj3; ERj3p; hDj-9

uniprot entry name :

DJB11_HUMAN

sequence length :

358

sequence :

MGSSHHHHHH SSGLVPRGSH MGRDFYKILG VPRSASIKDI KKAYRKLALQ LHPDRNPDDP QAQEKFQDLG AAYEVLSDSE KRKQYDTYGE EGLKDGHQSS HGDIFSHFFG DFGFMFGGTP RQQDRNIPRG SDIIVDLEVT LEEVYAGNFV EVVRNKPVAR QAPGKRKCNC RQEMRTTQLG PGRFQMTQEV VCDECPNVKL VNEERTLEVE IEPGVRDGME YPFIGEGEPH VDGEPGDLRF RIKVVKHPIF ERRGDDLYTN VTISLVESLV GFEMDITHLD GHKVHISRDK ITRPGAKLWK KGEGLPNFDN NNIKGSLIIT FDVDFPKEQL TEEAREGIKQ LLKQGSVQKV YNGLQGY

purity :

> 90% by SDS - PAGE

form :

Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl.

concentration :

0.5 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human. Tag: His-tag

other info2 :

Expression System: E Coli

products categories :

Heat Shock Proteins

products description :

DNAJB11 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. It serves as a co-chaperone for HSPA5 and binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. Recombinant human DNAJB11 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

products references :

Nakanishi K., et al. (2004) Cell Stress Chaperones. 9(3):253-64. Yu M., et al. (2000) J Biol Chem. 275(32):24984-92.

ncbi gi num :

7706495

ncbi acc num :

NP_057390

ncbi gb acc num :

NM_016306.5

ncbi mol weight :

40.5 kDa (357aa), confirmed by MALDI-TOF

ncbi pathways :

IRE1alpha Activates Chaperones Pathway (105906); Metabolism Of Proteins Pathway (106230); Protein Processing In Endoplasmic Reticulum Pathway (167325); Protein Processing In Endoplasmic Reticulum Pathway (167190); Unfolded Protein Response (UPR) Pathway (105904); XBP1(S) Activates Chaperone Genes Pathway (530771)

ncbi summary :

This gene encodes a soluble glycoprotein of the endoplasmic reticulum (ER) lumen that functions as a co-chaperone of binding immunoglobulin protein, a 70 kilodalton heat shock protein chaperone required for the proper folding and assembly of proteins in the ER. The encoded protein contains a highly conserved J domain of about 70 amino acids with a characteristic His-Pro-Asp (HPD) motif and may regulate the activity of binding immunoglobulin protein by stimulating ATPase activity. [provided by RefSeq, Mar 2014]

uniprot summary :

DNAJB11: Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. Protein type: RNA processing; Secreted; Endoplasmic reticulum; Chaperone; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 3q27.3. Cellular Component: membrane; endoplasmic reticulum lumen; endoplasmic reticulum; nucleus. Molecular Function: protein binding; unfolded protein binding. Biological Process: cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; protein folding; unfolded protein response; mRNA modification

size1 :

0.01 mg

price1 :

310 USD

size2 :

0.05 mg

price2 :

720

more info or order :

MyBioSource product webpage