catalog number :
MBS203685
products type :
Recombinant Protein
products full name :
CCL13, 24-98aa, Human, His tag, E Coli
products short name :
CCL13
products name syn :
CKb10; MCP-4; NCC-1; NCC1; SCYA1; SCYL1; CK-beta-10; Small-inducible cytokine A13; C-C motif chemokine 13; MCP4; C-C motif chemokine 13; chemokine (C-C motif) ligand 13; ckbeta10
other names :
C-C motif chemokine 13; C-C motif chemokine 13; C-C motif chemokine 13; CK-beta-10; monocyte chemoattractant protein 4; monocyte chemotactic protein 4; new CC chemokine 1; small inducible cytokine subfamily A (Cys-Cys), member 13; small-inducible cytokine A13; chemokine (C-C motif) ligand 13; CK-beta-10; Monocyte chemoattractant protein 4; Monocyte chemotactic protein 4; MCP-4; NCC-1; Small-inducible cytokine A13Cleaved into the following 3 chains:C-C motif chemokine 13, long chain; C-C motif chemokine 13, medium chain; C-C motif chemokine 13, short chain
products gene name :
CCL13
other gene names :
CCL13; CCL13; NCC1; CKb10; MCP-4; NCC-1; SCYL1; SCYA13; MCP4; NCC1; SCYA13; MCP-4
uniprot entry name :
CCL13_HUMAN
sequence :
MGSSHHHHHH SSGLVPRGSH MQPDALNVPS TCCFTFSSKK ISLQRLKSYV ITTSRCPQKA VIFRTKLGKE ICADPKEKWV QNYMKHLGRK AHTLKT
purity :
> 90% by SDS - PAGE
form :
Liquid. In Phosphate Buffered Saline pH7.4 containing 10% glycerol, 0.1M NaCl,1mM DTT
concentration :
0.25 mg/ml (determined by BCA assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)
products categories :
Hormones & Cytokines
products description :
CCL13 is a small cytokine belonging to the CC chemokine family that is also known as thymus and activation regulated chemokine (TARC). This protein induces chemotaxis in monocytes, eosinophils, T lymphocytes, and basophils by binding cell surface G-protein linked chemokine receptors such as CCR2, CCR3 and CCR5. It can be induced by the inflammatory cytokines interleukin-1 and TNF-alpha. Recombinant human CCL13 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Garcia-Zepeda EA, et al. (1996) J Immunol. 157:5613-5626
ncbi gb acc num :
NM_005408.2
ncbi mol weight :
10.8 kDa (96aa), confirmed by MALDI-TOF
ncbi pathways :
Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!NF-kappa B Signaling Pathway 634527
ncbi summary :
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014]