protein

TP53I3, 1-332aa, Human, His tag, E Coli

MBS203682

0.1 mg

285 USD

Recombinant Protein

TP53I3, 1-332aa, Human, His tag, E Coli

TP53I3

PIG3; Quinone oxidoreductase PIG3 p53 induced gene 3 protein; Putative quinone oxidoreductase; quinone oxidoreductase homolog; TP53I3; Tumor protein p53 inducible protein 3.

quinone oxidoreductase PIG3 isoform 1; Quinone oxidoreductase PIG3; quinone oxidoreductase PIG3; p53-induced gene 3 protein; quinone oxidoreductase homolog; tumor protein p53 inducible protein 3; Tumor protein p53-inducible protein 3; p53-induced gene 3 protein

TP53I3

TP53I3; TP53I3; PIG3; PIG3

QORX_HUMAN

332

MGSSHHHHHH SSGLVPRGSH MLAVHFDKPG GPENLYVKEV AKPSPGEGEV LLKVAASALN RADLMQRQGQ YDPPPGASNI LGLEASGHVA ELGPGCQGHW KIGDTAMALL PGGGQAQYVT VPEGLLMPIP EGLTLTQAAA IPEAWLTAFQ LLHLVGNVQA GDYVLIHAGL SGVGTAAIQL TRMAGAIPLV TAGSQKKLQM AEKLGAAAGF NYKKEDFSEA TLKFTKGAGV NLILDCIGGS YWEKNVNCLA LDGRWVLYGL MGGGDINGPL FSKLLFKRGS LITSLLRSRD NKYKQMLVNA FTEQILPHFS TEGPQRLLPV LDRIYPVTEI QEAHKYMEAN KNIGKIVLEL PQ

> 90% by SDS - PAGE

Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 0.1M NaCl

1 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Cancer

TP53I3, also known as quinone oxidoreductase PIG3, is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. It is localized to the cytoplasm and induced in primary, non-transformed and transformed cell cultures after exposure to genotoxic agents. This protein has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Recombinant human TP53I3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Flatt PM. et al. (2000) Cancer Lett. 156(1):63-72. Porte S, et al. (2009) J Biol Chem. 284(25):17194-205.

22538446

NP_671713

NM_147184.3

37.6 kDa (352aa), confirmed by MALDI-TOF

Direct P53 Effectors Pathway (137939); P53 Signaling Pathway (83055); P53 Signaling Pathway (465)

The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

TP53I3: May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro). Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Oxidoreductase; EC 1.-.-.-. Chromosomal Location of Human Ortholog: 2p23.3. Molecular Function: protein homodimerization activity; zinc ion binding; NADPH:quinone reductase activity; quinone binding. Biological Process: NADP metabolic process

0.1 mg

285 USD

0.5 mg

640