product summary
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company name :
MyBioSource
product type :
protein
product name :
SNuPN, 1-360aa, Human, His tag, E Coli
catalog :
MBS203669
quantity :
0.1 mg
price :
310 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS203669
products type :
Recombinant Protein
products full name :
SNuPN, 1-360aa, Human, His tag, E Coli
products short name :
SNuPN
products name syn :
KPNBL; RNuT1; Snurportin1; SPN1; Snurportin1
other names :
snurportin-1; Snurportin-1; snurportin-1; RNA U transporter 1; RNA, U transporter 1; snurportin 1; RNA U transporter 1
products gene name :
SNuPN
other gene names :
SNUPN; SNUPN; KPNBL; RNUT1; Snurportin1; RNUT1; SPN1
uniprot entry name :
SPN1_HUMAN
sequence length :
360
sequence :
MGSSHHHHHH SSGLVPRGSH MEELSQALAS SFSVSQDLNS TAAPHPRLSQ YKSKYSSLEQ SERRRRLLEL QKSKRLDYVN HARRLAEDDW TGMESEEENK KDDEEMDIDT VKKLPKHYAN QLMLSEWLID VPSDLGQEWI VVVCPVGKRA LIVASRGSTS AYTKSGYCVN RFSSLLPGGN RRNSTAKDYT ILDCIYNEVN QTYYVLDVMC WRGHPFYDCQ TDFRFYWMHS KLPEEEGLGE KTKLNPFKFV GLKNFPCTPE SLCDVLSMDF PFEVDGLLFY HKQTHYSPGS TPLVGWLRPY MVSDVLGVAV PAGPLTTKPD YAGHQLQQIM EHKKSQKEGM KEKLTHKASE NGHYELEHLS TPKLKGSSHS PDHPGCLMEN
purity :
> 90% by SDS - PAGE
form :
Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.1M NaCl
concentration :
1.0 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Adhesion & Movement
products description :
SNuPN, also known as KPNBL or RNuT1, is a nuclear import adaptor protein belonging to the Snurportin family. Localizing to the cytoplasm and nucleus, Snurportin-1 contains an N-terminal IBB domain and a trimethylguanosine (m3G)-cap binding domain. It specifically binds the terminal 2,2,7-m3G-cap at the 5' end of u snRNPs and functions to transport u snRNPs into the nucleus via an association with Importin beta. Recombinant human Snurportin-1 protien, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Huber J., et al. (1998) EMBO J. 17(14):4114-26.
ncbi gi num :
110611151
ncbi acc num :
NP_001036053
ncbi gb acc num :
NM_001042588.1
ncbi mol weight :
43.3 (380aa) confirmed by MALDI-TOF
ncbi pathways :
Gene Expression Pathway (105937); Metabolism Of Non-coding RNA Pathway (106228); RNA Transport Pathway (177876); RNA Transport Pathway (175229); SnRNP Assembly Pathway (106229)
ncbi summary :
The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
uniprot summary :
RNUT1: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. Belongs to the snurportin family. Protein type: Nuclear import; RNA-binding. Chromosomal Location of Human Ortholog: 15q24.2. Cellular Component: nuclear pore; cytosol. Molecular Function: RNA cap binding; protein transporter activity. Biological Process: spliceosomal snRNP biogenesis; protein import into nucleus; gene expression
size1 :
0.1 mg
price1 :
310 USD
size2 :
0.5 mg
price2 :
720
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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