Nicotinate nucleotide pyrophosphorylase (carboxylating) | MyBioSource MBS203645 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Nicotinate nucleotide pyrophosphorylase (carboxylating)

catalog :

MBS203645

quantity :

0.1 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS203645

products type :

Recombinant Protein

products full name :

Nicotinate nucleotide pyrophosphorylase (carboxylating)

products short name :

QPRT

products name syn :

Quinolinate phosphoribosyltransferase; QPRTase; QAPRTase

other names :

nicotinate-nucleotide pyrophosphorylase; Nicotinate-nucleotide pyrophosphorylase [carboxylating]; nicotinate-nucleotide pyrophosphorylase [carboxylating]; nicotinate-nucleotide pyrophosphorylase [carboxylating]; QAPRTase; epididymis secretory sperm binding protein Li 90n; nicotinate-nucleotide pyrophosphorylase (carboxylating); quinolinate phosphoribosyltransferase; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase; QPRTase

products gene name :

QPRT

other gene names :

QPRT; QPRT; QPRTase; HEL-S-90n; QAPRTase; QPRTase

uniprot entry name :

NADC_HUMAN

sequence length :

297

sequence :

MGSSHHHHHH SSGLVPRGSH MDAEGLALLL PPVTLAALVD SWLREDCPGL NYAALVSGAG PSQAALWAKS PGVLAGQPFF DAIFTQLNCQ VSWFLPEGSK LVPVARVAEV RGPAHCLLLG ERVALNTLAR CSGIASAAAA AVEAARGAGW TGHVAGTRKT TPGFRLVEKY GLLVGGAASH RYDLGGLVMV KDNHVVAAGG VEKAVRAARQ AADFALKVEV ECSSLQEAVQ AAEAGADLVL LDNFKPEELH PTATVLKAQF PSVAVEASGG ITLDNLPQFC GPHIDVISMG MLTQAAPALD FSLKLFAKEV APVPKIH

purity :

> 95% by SDS - PAGE

form :

Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol

concentration :

1mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human. Tag: His-tag

other info2 :

Expression System: E Coli

products categories :

Neuroscience

products description :

Quinolinate phosphoribosyltransferase, also known as QPRT, is a major enzyme in the catabolism of quinolinate. It is an intermediate in the tryptophannicotinamide adenine dinucleotide (NAD) pathway, leading to the production of nicotinic acid, carbon dioxide and pyrophosphate. Elevation of QPRT levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Recombinant human QPRT protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

products references :

Delaney J., et al. (2005) Arch Toxicol. 79(2):208-223. Eads J C., et al. (1997) Structure. 5:47-58.

ncbi gi num :

45269149

ncbi acc num :

NP_055113

ncbi gb acc num :

NM_014298.3

ncbi mol weight :

32.9 kDa (317aa), confirmed by MALDI-TOF

ncbi pathways :

Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway (906000); Defective BTD Causes Biotidinase Deficiency Pathway (906015); Defective CD320 Causes Methylmalonic Aciduria Pathway (906012); Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway (906001); Defective GIF Causes Intrinsic Factor Deficiency Pathway (906004); Defective HLCS Causes Multiple Carboxylase Deficiency Pathway (906014); Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway (906003); Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway (906010); Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway (906009); Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway (906005)

ncbi summary :

This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. [provided by RefSeq, Jul 2008]

uniprot summary :

QPRT: Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Transferase; EC 2.4.2.19. Chromosomal Location of Human Ortholog: 16p11.2. Cellular Component: cytoplasm; cytosol. Molecular Function: protein homodimerization activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity. Biological Process: NAD biosynthetic process; vitamin metabolic process; NAD metabolic process; protein oligomerization; water-soluble vitamin metabolic process

size1 :

0.1 mg

price1 :

310 USD

size2 :

0.5 mg

price2 :

720

more info or order :

MyBioSource product webpage