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company name :
MyBioSource
product type :
protein
product name :
OAT, 33-439aa, Human, E Coli
catalog :
MBS203639
quantity :
0.1 mg
price :
285 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS203639
products type :
Recombinant Protein
products full name :
OAT, 33-439aa, Human, E Coli
products short name :
OAT
products name syn :
DKFZp781A11155; HOGA; OATASE; ornithine aminotransferase precursor EC 2.6.1.13; ornithine aminotransferase (gyrate atrophy); ornithine aminotransferase precursor; Ornithine aminotransferase; mitochondrial precursor; Ornithine oxo-acid aminotransferase; Ornithine--oxo-acid aminotransferase.
other names :
ornithine aminotransferase, mitochondrial isoform 1; Ornithine aminotransferase, mitochondrial; ornithine aminotransferase, mitochondrial; gyrate atrophy; ornithine delta-aminotransferase; ornithine-oxo-acid aminotransferase; ornithine aminotransferase; Ornithine delta-aminotransferase; Ornithine--oxo-acid aminotransferaseCleaved into the following 2 chains:Ornithine aminotransferase, hepatic form; Ornithine aminotransferase, renal form
products gene name :
OAT
other gene names :
OAT; OAT; OKT; GACR; HOGA; OATASE
uniprot entry name :
OAT_HUMAN
sequence length :
439
sequence :
MTVQGPPTSD DIFEREYKYG AHNYHPLPVA LERGKGIYLW DVEGRKYFDF LSSYSAVNQG HCHPKIVNAL KSQVDKLTLT SRAFYNNVLG EYEEYITKLF NYHKVLPMNT GVEAGETACK LARKWGYTVK GIQKYKAKIV FAAGNFWGRT LSAISSSTDP TSYDGFGPFM PGFDIIPYND LPALERALQD PNVAAFMVEP IQGEAGVVVP DPGYLMGVRE LCTRHQVLFI ADEIQTGLAR TGRWLAVDYE NVRPDIVLLG KALSGGLYPV SAVLCDDDIM LTIKPGEHGS TYGGNPLGCR VAIAALEVLE EENLAENADK LGIILRNELM KLPSDVVTAV RGKGLLNAIV IKETKDWDAW KVCLRLRDNG LLAKPTHGDI IRFAPPLVIK EDELRESIEI INKTILSF
purity :
> 90% by SDS - PAGE
form :
Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol
concentration :
1.0 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human
other info2 :
Expression System: E Coli
products categories :
Enzymes & Proteases
products description :
OAT, also known as mitochondrial enzyme ornithine aminotransferase, is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. (L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.) Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Recombinant OAT protein was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Mitchell GA., et al. (1988) J. Biol. Chem. 263(28):14288-95. Shah SA., et al. (1997) Structure. 5(8):1067-75.
ncbi gi num :
4557809
ncbi acc num :
NP_000265
ncbi gb acc num :
NM_000274.3
ncbi mol weight :
45.2 kDa (408aa), confirmed by MALDI-TOF.
ncbi pathways :
Amino Acid Synthesis And Interconversion (transamination) Pathway 106173!!Arginine And Proline Metabolism Pathway 82957!!Arginine And Proline Metabolism Pathway 323!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!Metabolism Of Amino Acids And Derivatives Pathway 106169!!Urea Cycle And Metabolism Of Amino Groups Pathway 198758!!Arginine Degradation I (arginase Pathway) 138167!!Citrulline Biosynthesis Pathway 138212!!Ornithine De Novo Biosynthesis Pathway 142133
ncbi summary :
This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010]
size :
0.1 mg
price :
285 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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