protein

CTNNBIP1, 1-81aa, Human, His tag, E Coli

MBS203632

0.1 mg

285 USD

Recombinant Protein

CTNNBIP1, 1-81aa, Human, His tag, E Coli

CTNNBIP1

ICAT; Beta-catenin-interacting protein 1; Beta catenin interacting protein1; Beta catenin interacting protein ICAT; Catenin beta interacting protein 1; CTNNBIP 1; ICAT; Inhibitor of beta catenin and Tcf 4; MGC15093

beta-catenin-interacting protein 1; Beta-catenin-interacting protein 1; beta-catenin-interacting protein 1; beta-catenin-interacting protein ICAT; inhibitor of beta-catenin and Tcf-4; catenin, beta interacting protein 1; Inhibitor of beta-catenin and Tcf-4

CTNNBIP1

CTNNBIP1; CTNNBIP1; ICAT; ICAT

CNBP1_HUMAN

81

MGSSHHHHHH SSGLVPRGSH MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTASEEEF LRTYAGVVNS QLSQLPPHSI DQGAEDVVMA FSRSETEDRR Q

> 90% by SDS - PAGE

Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 2mM DTT, 100mM NaCl

1mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Signal Transduction

CTNNBIP1 binds CTNNB1 and prevents interaction between CTNNB1 and TCF (T-cell transcription factor) family members. This protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. Recombinant human CTNNBIP1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography

Tago K., et al. (2000) Genes Dev. 14 (14): 1741-9. Daniels D.L., et al. (2002) Mol Cell 10:573-584.

9910390

NP_064633

NM_020248.2

11.3kDa (101a) confirmed by MALDI-TOF

Disease Pathway (530764); RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway (1127632); Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway (169352); Signal Transduction Pathway (477114); Signaling By WNT In Cancer Pathway (1127614); Signaling By Wnt Pathway (106510); TCF Dependent Signaling In Response To WNT Pathway (1127516); Wnt Signaling Pathway NetPath (198799); Wnt Signaling Pathway (83061); Wnt Signaling Pathway (471)

The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

CTNNBIP1: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. Belongs to the CTNNBIP1 family. Protein type: Inhibitor; Cell development/differentiation. Chromosomal Location of Human Ortholog: 1p36.22. Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol; beta-catenin destruction complex. Molecular Function: protein binding; beta-catenin binding. Biological Process: anterior/posterior pattern formation; positive regulation of monocyte differentiation; positive regulation of osteoblast differentiation; negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway; negative regulation of smooth muscle cell proliferation; ureteric bud branching; negative regulation of transcription factor activity; negative regulation of protein binding; regulation of vascular permeability during acute inflammatory response; negative regulation of DNA binding

0.1 mg

285 USD

0.5 mg

640