HRP-Linked Monoclonal Antibody to Interleukin 10 (IL10) | MyBioSource MBS2036286 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

HRP-Linked Monoclonal Antibody to Interleukin 10 (IL10)

catalog :

MBS2036286

quantity :

0.1 mg

price :

190 USD

clonality :

monoclonal

host :

mouse

conjugate :

HRP

clone name :

[C8]

reactivity :

human

application :

immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2036286

products type :

Antibody

products full name :

HRP-Linked Monoclonal Antibody to Interleukin 10 (IL10)

products short name :

[Interleukin 10 (IL10)]

other names :

[interleukin-10; Interleukin-10; interleukin-10; interleukin 10; Cytokine synthesis inhibitory factor; CSIF]

products gene name :

[IL10]

other gene names :

[IL10; IL10; CSIF; TGIF; GVHDS; IL-10; IL10A; IL-10; CSIF]

clonality :

Monoclonal

isotype :

IgG2a Kappa

clone :

[C8]

host :

Mouse

reactivity :

Homo sapiens (Human)

purity :

Protein A/G Affinity Chromatography.

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

concentration :

1mg/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37oC for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date underappropriate storage condition. Note: As fluorescence can photobleach when exposed to light, so the antibody must be protected from light.

tested application :

IHC; ICC.

app notes :

Western blotting: 0.5-2,Ug/mL . Immunohistochemistry: 5-20, Ug/mL . Immunocytochemistry: 5-20,Ug/mL. Optimal working dilutions must be determined by end user.

other info1 :

. Source: Monoclonal antibody preparation. Label: HRP. Traits: Liquid. Immunogen: Recombinant IL10 (Met1~Asn178) expressed in E.coli.

other info2 :

Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2085804

ncbi gi num :

10835141

ncbi acc num :

NP_000563.1

ncbi gb acc num :

NM_000572.2

uniprot acc num :

P22301

ncbi mol weight :

20,517 Da

ncbi pathways :

African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Asthma Pathway (83120); Asthma Pathway (532); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533)

ncbi summary :

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]

uniprot summary :

IL10: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. Belongs to the IL-10 family. Protein type: Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1q32.1. Cellular Component: extracellular space. Molecular Function: cytokine activity; interleukin-10 receptor binding; protein binding. Biological Process: cell-cell signaling; hemopoiesis; inflammatory response; leukocyte chemotaxis; negative regulation of B cell proliferation; negative regulation of cell proliferation; negative regulation of cytokine secretion during immune response; negative regulation of heterotypic cell-cell adhesion; negative regulation of interleukin-1 production; negative regulation of interleukin-12 production; negative regulation of interleukin-18 production; negative regulation of interleukin-6 production; negative regulation of interleukin-8 production; negative regulation of membrane protein ectodomain proteolysis; negative regulation of MHC class II biosynthetic process; negative regulation of mitotic cell cycle; negative regulation of tumor necrosis factor production; positive regulation of B cell apoptosis; positive regulation of cytokine secretion; positive regulation of heterotypic cell-cell adhesion; positive regulation of JAK-STAT cascade; positive regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; receptor biosynthetic process; regulation of gene expression; response to glucocorticoid stimulus; response to molecule of bacterial origin; T-helper 2 type immune response. Disease: Graft-versus-host Disease, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To; Rheumatoid Arthritis

size1 :

0.1 mg

price1 :

190 USD

size2 :

0.2 mg

price2 :

245

size3 :

1 mg

price3 :

550

more info or order :

MyBioSource product webpage