product summary
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company name :
MyBioSource
product type :
antibody
product name :
PE-Linked Monoclonal Antibody to Insulin Like Growth Factor 1 (IGF1)
catalog :
MBS2036086
quantity :
0.1 mg
price :
175 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE
reactivity :
cow
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
product information
catalog number :
MBS2036086
products type :
Antibody
products full name :
PE-Linked Monoclonal Antibody to Insulin Like Growth Factor 1 (IGF1)
products short name :
[Insulin Like Growth Factor 1 (IGF1)]
other names :
[insulin-like growth factor 1, partial; Insulin-like growth factor I; insulin-like growth factor I; Somatomedin]
products gene name :
[IGF1]
other gene names :
[IGF1; IGF1; IGF-1; IGF-I; IGF-I]
clonality :
Monoclonal
host :
Mouse
purity :
Protein A/G Affinity Chromatography.
form :
Supplied as solution form in 10 mM Tris, 150 mM NaCl, pH 8.2 50% glycerol, 0.05% Proclin-300
concentration :
0.27 mg/ml
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37oC for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
WB; IHC; ICC.
app notes :
Western blotting: 0.5-2 ug/mL;1:130-500. Immunohistochemistry: 5-20 ug/mL;1:13-50. Immunocytochemistry: 5-20 ug/mL;1:13-50. Optimal working dilutions must be determined by end user.
other info1 :
Organism Species: Homo sapiens (Human). Source: Monoclonal antibody preparation. Clone number: C1. Label: PE. Traits: Liquid. Immunogen: Recombinant IGF1 (Gly49~Ala118) expressed in E.coli.
other info2 :
Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2085800
ncbi gi num :
4261909
ncbi acc num :
AAD14209.1
ncbi pathways :
AMPK Signaling Pathway (989258); AMPK Signaling Pathway (992181); Adipogenesis Pathway (920913); Aldosterone-regulated Sodium Reabsorption Pathway (130625); Aldosterone-regulated Sodium Reabsorption Pathway (130590); Apoptosis Pathway (198572); Breast Cancer Pathway (1435193); Breast Cancer Pathway (1435182); Cardiac Hypertrophic Response Pathway (1458463); Cardiac Progenitor Differentiation Pathway (1458415)
uniprot summary :
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 ().
size1 :
0.1 mg
price1 :
175 USD
size2 :
0.2 mg
price2 :
225
size3 :
1 mg
price3 :
510
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

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