antibody

PE-Linked Monoclonal Antibody to Insulin Like Growth Factor 1 (IGF1)

MBS2036086

0.1 mg

175 USD

monoclonal

mouse

PE

western blot, immunohistochemistry, immunocytochemistry

Antibody

PE-Linked Monoclonal Antibody to Insulin Like Growth Factor 1 (IGF1)

[Insulin Like Growth Factor 1 (IGF1)]

[insulin-like growth factor 1, partial; Insulin-like growth factor I; insulin-like growth factor I; Somatomedin]

[IGF1]

[IGF1; IGF1; IGF-1; IGF-I; IGF-I]

Monoclonal

Mouse

Protein A/G Affinity Chromatography.

Supplied as solution form in 10 mM Tris, 150 mM NaCl, pH 8.2 50% glycerol, 0.05% Proclin-300

0.27 mg/ml

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37oC for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

WB; IHC; ICC.

Western blotting: 0.5-2 ug/mL;1:130-500. Immunohistochemistry: 5-20 ug/mL;1:13-50. Immunocytochemistry: 5-20 ug/mL;1:13-50. Optimal working dilutions must be determined by end user.

Organism Species: Homo sapiens (Human). Source: Monoclonal antibody preparation. Clone number: C1. Label: PE. Traits: Liquid. Immunogen: Recombinant IGF1 (Gly49~Ala118) expressed in E.coli.

Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2085800

4261909

AAD14209.1

AMPK Signaling Pathway (989258); AMPK Signaling Pathway (992181); Adipogenesis Pathway (920913); Aldosterone-regulated Sodium Reabsorption Pathway (130625); Aldosterone-regulated Sodium Reabsorption Pathway (130590); Apoptosis Pathway (198572); Breast Cancer Pathway (1435193); Breast Cancer Pathway (1435182); Cardiac Hypertrophic Response Pathway (1458463); Cardiac Progenitor Differentiation Pathway (1458415)

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 ().

0.1 mg

175 USD

0.2 mg

225

1 mg

510