catalog number :
MBS203602
products type :
Recombinant Protein
products full name :
FBP1, 1-338aa, Human, His-tag, E Coli
products short name :
FBP1
products name syn :
FBPase1; FBP; FBP1; D fructose 1 6 bisphosphate 1 phosphohydrolase 1; EC 3.1.3.11; FBP 1; FBPase 1; Fructose 1 6 bisphosphatase 1 Fructose bisphosphatase 1; Growth inhibiting protein 17; Liver fructose bisphosphatase.
other names :
fructose-1,6-bisphosphatase 1; Fructose-1,6-bisphosphatase 1; fructose-1,6-bisphosphatase 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; FBPase 1; fructose-bisphosphatase 1; growth-inhibiting protein 17; liver FBPase; fructose-1,6-bisphosphatase 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; Liver FBPase
products gene name :
FBP1
other gene names :
FBP1; FBP1; FBP; FBP; FBPase 1
uniprot entry name :
F16P1_HUMAN
sequence :
MGSSHHHHHH SSGLVPRGSH MADQAPFDTD VNTLTRFVME EGRKARGTGE LTQLLNSLCT AVKAISSAVR KAGIAHLYGI AGSTNVTGDQ VKKLDVLSND LVMNMLKSSF ATCVLVSEED KHAIIVEPEK RGKYVVCFDP LDGSSNIDCL VSVGTIFGIY RKKSTDEPSE KDALQPGRNL VAAGYALYGS ATMLVLAMDC GVNCFMLDPA IGEFILVDKD VKIKKKGKIY SLNEGYARDF DPAVTEYIQR KKFPPDNSAP YGARYVGSMV ADVHRTLVYG GIFLYPANKK SPNGKLRLLY ECNPMAYVME KAGGMATTGK EAVLDVIPTD IHQRAPVILG SPDDVLEFLK VYEKHSAQ
purity :
> 90% by SDS - PAGE
form :
Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Metabolism
products description :
Fructose-1,6-bisphosphatase 1(FBP1) is a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. Recombinant FBP1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Rabenhorst u., et al. (2009) Hepatology. 50(4):1121-9. Hirota K., et al. (2008) Nature. 456(7218):130-4.
ncbi acc num :
NP_000498.2
ncbi gb acc num :
NM_000507.3
ncbi mol weight :
39.0 kDa (358aa), confirmed by MALDI-TOF.
ncbi pathways :
AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!Carbon Metabolism Pathway 814926!!Carbon Metabolism Pathway 817567!!Disease Pathway 530764!!Fructose And Mannose Metabolism Pathway 82930!!Fructose And Mannose Metabolism Pathway 291!!Gluconeogenesis Pathway 106204!!Gluconeogenesis, Oxaloacetate = Fructose-6P Pathway 413342!!Gluconeogenesis, Oxaloacetate = Fructose-6P Pathway 468196
ncbi summary :
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]