protein

SNCA, 1-140aa, Mouse, E Coli

MBS203580

0.1 mg

310 USD

Recombinant Protein

SNCA, 1-140aa, Mouse, E Coli

SNCA

Snca; Syn; alpha-Synuclein; NACP; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor

alpha-synuclein; Alpha-synuclein; alpha-synuclein; non-A beta component of AD amyloid; non-A4 component of amyloid; synuclein, alpha; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP

SNCA

Snca; Snca; NACP; alphaSYN; Syn; NACP

SYUA_MOUSE

140

MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM GKGEEGYPQE GILEDMPVDP GSEAYEMPSE EGYQDYEPEA

> 95% by SDS - PAGE

Liquid. In 20mM Tris-HCl buffer (pH 7.5) containing, 10% glycerol

1mg/ml (determined by BCA assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Mouse

Expression System: E Coli

Neuroscience

Alpha-Synuclein, also known as SNCA, an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. alpha-Synuclein has been suggested to be implicated in the pathogenesis of Parkinson. Recombinant mouse alpha-Synuclein, was expressed in E.coli and purified by using conventional chromatography techniques

ueda K., et al. (1993) Proc. Natl. Acad. Sci. uSA 90:11282-11286 . Kim J., et al. (1997) Molecules and Cells 7:78-83 . Jakes R., et al. (1994) FEBS lett. 345:27-32.

6678047

NP_033247

NM_009221.2

14.4 kDa (140aa), confirmed by MALDI-TOF

Alzheimer's Disease Pathway (83294); Alzheimer's Disease Pathway (509); Amyloids Pathway (1111331); Disease Pathway (1111319); EGFR1 Signaling Pathway (198278); Parkinson's Disease Pathway (83295)

SNCA: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson s disease. A major component of amyloid plaques in the brains of patients with Alzheimer s disease. Two alternatively spliced isoforms transcripts have been identified. Protein type: Adaptor/scaffold. Cellular Component: Golgi apparatus; nuclear outer membrane; mitochondrion; terminal button; inclusion body; cytosol; platelet alpha granule membrane; synaptic vesicle; perinuclear region of cytoplasm; cytoplasm; synapse; cytoplasmic vesicle membrane; rough endoplasmic reticulum; intracellular membrane-bound organelle; cell; fibril; cell cortex; actin cytoskeleton; cytoskeleton; growth cone; axon; plasma membrane; ribosome; nerve terminal; nucleus. Molecular Function: identical protein binding; histone binding; zinc ion binding; kinesin binding; metal ion binding; ferrous iron binding; magnesium ion binding; calcium ion binding; oxidoreductase activity; Hsp70 protein binding; enzyme binding; phospholipase binding; phospholipid binding; alpha-tubulin binding; protein domain specific binding; microtubule binding; caspase inhibitor activity; beta-tubulin binding; protein N-terminus binding; phosphoprotein binding; arachidonic acid binding; dynein binding; protein binding; copper ion binding; tau protein binding. Biological Process: regulation of acyl-CoA biosynthetic process; adult locomotory behavior; regulation of neurotransmitter secretion; response to lipopolysaccharide; positive regulation of endocytosis; dopamine biosynthetic process; positive regulation of neurotransmitter secretion; dopamine metabolic process; response to magnesium ion; regulation of neuron apoptosis; synapse organization and biogenesis; negative regulation of neuron apoptosis; response to drug; negative regulation of dopamine metabolic process; synaptic vesicle endocytosis; negative regulation of transporter activity; regulation of neuronal synaptic plasticity; negative regulation of apoptosis; regulation of long-term neuronal synaptic plasticity; negative regulation of serotonin uptake; synaptic transmission, dopaminergic; negative regulation of norepinephrine uptake; mitochondrial membrane organization and biogenesis; microglial cell activation; negative regulation of caspase activity; negative regulation of monooxygenase activity; fatty acid metabolic process; regulation of dopamine secretion; positive regulation of synaptic transmission; negative regulation of dopamine uptake; negative regulation of histone acetylation; synaptic transmission; negative regulation of exocytosis; negative regulation of protein amino acid phosphorylation; behavioral response to cocaine; receptor internalization; phospholipid metabolic process; response to iron(II) ion; positive regulation of receptor recycling; caspase activation; neutral lipid metabolic process; protein destabilization; regulation of glutamate secretion; regulation of macrophage activation; negative regulation of microtubule polymerization; synaptic vesicle transport; positive regulation of peptidyl-serine phosphorylation; organelle ATP synthesis coupled electron transport; regulation of locomotion; positive regulation of release of sequestered calcium ion into cytosol; regulation of excitatory postsynaptic membrane potential

0.1 mg

310 USD

0.5 mg

720