catalog number :
MBS203529
products type :
Recombinant Protein
products full name :
MAGOH, 1-146aa, Human, His-tag, Recombinant, E Coli
products short name :
MAGOH
products name syn :
MAGOH1; MAGOHA; Protein mago nashi homolog Mago nashi homolog proliferation associated (Drosophila); Mago nashi protein homolog
other names :
protein mago nashi homolog; Protein mago nashi homolog; protein mago nashi homolog; mago-nashi homolog, proliferation-associated (Drosophila)
products gene name :
MAGOH
other gene names :
MAGOH; MAGOH; MAGOH1; MAGOHA; MAGOHA
uniprot entry name :
MGN_HUMAN
sequence :
MESDFYLRYY VGHKGKFGHE FLEFEFRPDG KLRYANNSNY KNDVMIRKEA YVHKSVMEEL KRIIDDSEIT KEDDALWPPP DRVGRQELEI VIGDEHISFT TSKIGSLIDV NQSKDPEGLR VFYYLVQDLK CLVFSLIGLH FKIKPILEHH HHHH
purity :
> 90% by SDS - PAGE
form :
Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 2mM DTT, 0.1M NaCl, 20% glycerol
concentration :
0.5 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Transcription & Translation
products description :
MAGOH, the human homolog of Drosophila mago nashi, is required for embryo development. MAGOH is ubiquitously expressed in adult tissues. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. Recombinant human MAGOH protein, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Gehring NH., et al. (2009) Cell. 137(3):536-48. Chamieh H., et al. (2008) Nat Struct Mol Biol. 15(1):85-93.
ncbi gb acc num :
NM_002370.3
ncbi mol weight :
18.2 kDa (154aa), confirmed by MALDI-TOF
ncbi pathways :
Cleavage Of Growing Transcript In The Termination Region Pathway 106560!!Exon Junction Complex (EJC) Pathway 470353!!Exon Junction Complex (EJC) Pathway 890638!!Gene Expression Pathway 105937!!Nonsense Mediated Decay (NMD) Enhanced By The Exon Junction Complex (EJC) Pathway 366241!!Nonsense-Mediated Decay (NMD) Pathway 366240!!Processing Of Capped Intron-Containing Pre-mRNA Pathway 160950!!RNA Polymerase II Transcription Pathway 106557!!RNA Polymerase II Transcription Termination Pathway 106559!!RNA Transport Pathway 177876
ncbi summary :
Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008]