protein

RARalpha, 68-173aa, Human, His-tag, Recombinant, E Coli

MBS203527

0.1 mg

310 USD

Recombinant Protein

RARalpha, 68-173aa, Human, His-tag, Recombinant, E Coli

RARalpha

NR1B1; Retinoic acid receptor alpha; Retinoic acid receptor; alpha isoform 1; RAR alpha; RARalpha; RAR; Retinoic acid receptor; alpha isoform 1

retinoic acid receptor alpha isoform 1; Retinoic acid receptor alpha; retinoic acid receptor alpha; RAR-alpha; nuclear receptor subfamily 1 group B member 1; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear receptor alpha variant 2; retinoic acid receptor, alpha polypeptide; retinoic acid receptor, alpha; Nuclear receptor subfamily 1 group B member 1

RARalpha

RARA; RARA; RAR; NR1B1; NR1B1; RAR-alpha

RARA_HUMAN

462

MGSSHHHHHH SSGLVPRGSH MSEEIVPSPP SPPPLPRIYK PCFVCQDKSS GYHYGVSACE GCKGFFRRSI QKNMVYTCHR DKNCIINKVT RNRCQYCRLQ KCFEVGMSKE SVRNDRNKKK KEVPKPE

> 95% by SDS-PAGE

Liquid in 20mM Tris pH 7.5, 0.1M NaCl, 5mM beta-mercaptoethanol

1 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Cell Cycle

Retinoic acid receptors (RAR) belong to the large family of ligand responsive gene regulatory proteins that includes receptors for steroid and thyroid hormones. These proteins contain two highly conserved domains that are involved in determining their DNA and ligand-binding activities. Three isotypes of RARs, alpha, beta, and gamma, are encoded by distinct genetic loci and possess distinct transcriptional properties. Typically, RAR-alpha represses target gene transcription in the absence of hormone, whereas RAR-beta and gamma fail to repress under these conditions. Recombinant human RARalpha, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Kliewer SA., et al. (1992) Nature. 355, 446-9. Gillespie RF., et al. (2007) J. Biol. Chem. 282, 33421-34.

4506419

NP_000955

NM_000964.3

14 kDa (127 aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)

Acute Myeloid Leukemia Pathway 83117!!Acute Myeloid Leukemia Pathway 529!!Adipogenesis Pathway 198832!!Gene Expression Pathway 105937!!Generic Transcription Pathway 105938!!IL-3 Signaling Pathway 198881!!Integrated Pancreatic Cancer Pathway 711360!!Nuclear Receptor Transcription Pathway 105979!!Nuclear Receptors Pathway 198848!!Nuclear Receptors In Lipid Metabolism And Toxicity Pathway 198887

This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]

0.1 mg

310 USD