product summary
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company name :
MyBioSource
product type :
protein
product name :
NQO2, 1-231aa, Human, His tag, E Coli
catalog :
MBS203514
quantity :
0.1 mg
price :
285 USD
more info or order :
image
image 1 :
product information
catalog number :
MBS203514
products type :
Recombinant Protein
products full name :
NQO2, 1-231aa, Human, His tag, E Coli
products short name :
[NQO2]
products name syn :
[Ribosyldihydronicotinamide dehydrogenase; DHQV; DIA6; QR2; Ribosyldihydronicotinamide dehydrogenase Ox2; EC 1.10.99.2; MGC94180; NAD (P)H dehydrogenase quinone 2; NAD (P)H menadione oxidoreductase 1 dioxin inducible 2; NAD (P)H menadione oxidoreductase 2 dioxin inducible; NMOR2; NQO 2; NRH dehydrogenase; NRH:quinone oxidoreductase 2; OTTHuMP00000015948; OTTHuMP00000015949; OTTHuMP00000015953; Ox 2; QR2; Quinone; Quinone reductase 2; Ribosyldihydronicotinamide dehydrogenase.]
other names :
[NAD(P)H dehydrogenase, quinone 2; Ribosyldihydronicotinamide dehydrogenase [quinone]; ribosyldihydronicotinamide dehydrogenase [quinone]; N-ribosyldihydronicotinamide:quinone reductase 2; NRH dehydrogenase [quinone] 2; NRH:quinone oxidoreductase 2; Quinone reductase 2; QR2]
products gene name :
[NQO2]
other gene names :
[NQO2; NQO2; QR2; DHQV; DIA6; NMOR2; NMOR2; QR2]
host :
E Coli
sequence length :
231
sequence :
MGSSHHHHHH SSGLVPRGSH MAGKKVLIVY AHQEPKSFNG SLKNVAVDEL SRQGCTVTVS DLYAMNFEPR ATDKDITGTL SNPEVFNYGV ETHEAYKQRS LASDITDEQK KVREADLVIF QFPLYWFSVP AILKGWMDRV LCQGFAFDIP GFYDSGLLQG KLALLSVTTG GTAEMYTKTG VNGDSRYFLW PLQHGTLHFC GFKVLAPQIS FAPEIASEEE RKGMVAAWSQ RLQTIWKEEP IPCTAHWHFG Q
purity :
> 95% by SDS-PAGE
form :
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol, 1mM DTT.
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
image1 heading :
SDS-Page
other info1 :
Antigen Species: Human. Tag Information: His-tag
products categories :
Redox Proteins
products description :
NQO2 is a member of the NAD (P)H dehydrogenase (quinone). The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. It is flavoproteins that catalyze the metabolic detoxification of quinones and their derivatives to hydroquinones. This detoxification process protects cells against quinone-induced oxidative stress, cytotoxicity and mutagenicity. Recombinant human NQO2 protein was expressed in E Coli and purified by using conventional chromatography techniques.
products references :
Wu K., et al. (1997) Arch Biochem Biophys. 347 (2):221-8. ; Jaiswal AK., et al. (1994) J Biol Chem. 269 (20):14502-8. ;
ncbi gi num :
13543901
ncbi acc num :
AAH06096
ncbi mol weight :
28.1 kDa (251aa), confirmed by MALDI-TOF.
ncbi pathways :
Biological Oxidations Pathway (1270189); Metabolism Pathway (1269956); Phase 1 - Functionalization Of Compounds Pathway (1270190); Photodynamic Therapy-induced NFE2L2 (NRF2) Survival Signaling Pathway (1458289)
ncbi summary :
This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
uniprot summary :
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
size1 :
0.1 mg
price1 :
285 USD
size2 :
0.5 mg
price2 :
640
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
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