product summary
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company name :
MyBioSource
product type :
protein
product name :
CAPG, 1-348aa, Human, E Coli
catalog :
MBS203494
quantity :
0.1 mg
price :
285 USD
more info or order :
product information
catalog number :
MBS203494
products type :
Recombinant Protein
products full name :
CAPG, 1-348aa, Human, E Coli
products short name :
CAPG
products name syn :
MCP; AFCP; Macrophage-capping protein Actin capping protein GCAP39; Actin regulatory protein CAP G; CAPG; Capping protein (actin filament) gelsolin like; Capping protein gelsolin like; gCap39; Gelsolin like capping protein; Macrophage capping protein; mbh1; Myc basic motif homolog 1
other names :
Capping protein (actin filament), gelsolin-like; Macrophage-capping protein; macrophage-capping protein; actin regulatory protein CAP-G; actin-regulatory protein CAP-G; epididymis secretory protein Li 66; gelsolin-like capping protein; macrophage capping protein; capping protein (actin filament), gelsolin-like; Actin regulatory protein CAP-G
products gene name :
CAPG
other gene names :
CAPG; CAPG; MCP; AFCP; HEL-S-66; AFCP; MCP
uniprot entry name :
CAPG_HUMAN
sequence length :
348
sequence :
MYTAIPQSGS PFPGSVQDPG LHVWRVEKLK PVPVAQENQG VFFSGDSYLV LHNGPEEVSH LHLWIGQQSS RDEQGACAVL AVHLNTLLGE RPVQHREVQG NESDLFMSYF PRGLKYQEGG VESAFHKTST GAPAAIKKLY QVKGKKNIRA TERALNWDSF NTGDCFILDL GQNIFAWCGG KSNILERNKA RDLALAIRDS ERQGKAQVEI VTDGEEPAEM IQVLGPKPAL KEGNPEEDLT ADKANAQAAA LYKVSDATGQ MNLTKVADSS PFALELLISD DCFVLDNGLC GKIYIWKGRK ANEKERQAAL QVAEGFISRM QYAPNTQVEI LPQGRESPIF KQFFKDWK
purity :
> 95% by SDS - PAGE
form :
Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human
other info2 :
Expression System: E Coli
products categories :
Immunology
products description :
Macrophage-capping protein, also known as CAPG, belongs to the gelsolin/villin family of actin-regulatory proteins. CAPG is a calcium-sensitive DNA-binding protein that plays a role in macrophage function. It is expressed in macrophages and macrophage-like cells and can localize both to the nucleus and the cytoplasm. This protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. Recombinant human CAPG was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Dabiri G A., et al. (1992) J Biol Chem. 267:16545-16552. Pellieux C., et al. (2003) J Biol Chem. 278(3):29136-44.
ncbi gi num :
12653873
ncbi acc num :
AAH00728
ncbi mol weight :
38.5 kDa (348aa), confirmed by MALDI-TOF.
ncbi summary :
This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]
uniprot summary :
CAPG: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. Belongs to the villin/gelsolin family. Protein type: Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 2p11.2. Cellular Component: F-actin capping protein complex; melanosome; nucleus. Molecular Function: actin binding. Biological Process: protein complex assembly; cell projection biogenesis; barbed-end actin filament capping
size1 :
0.1 mg
price1 :
285 USD
size2 :
0.5 mg
price2 :
640
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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