product summary
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company name :
MyBioSource
product type :
protein
product name :
Prostagladin E synthase 3, 1-160aa, Human, E Coli
catalog :
MBS203477
quantity :
0.1 mg
price :
375 USD
more info or order :
product information
catalog number :
MBS203477
products type :
Recombinant Protein
products full name :
Prostagladin E synthase 3, 1-160aa, Human, E Coli
products short name :
Prostagladin E synthase 3
products name syn :
PTGES3; cPGES; P23; TEBP; HSP90 co-chaperone; Sid 3177; Co chaperone p23; Hsp90 co chaperone; Cytosolic prostaglandin E2 synthase; Progesterone receptor complex; Progesterone receptor complex p23; Prostaglandin E synthase 3; PTGES 3; Telomerase binding protein p23; unactive progesterone receptor 23 kD
other names :
prostaglandin E synthase 3 isoform a; Prostaglandin E synthase 3; prostaglandin E synthase 3; Hsp90 co-chaperone; cytosolic prostaglandin E synthase; cytosolic prostaglandin E2 synthase; progesterone receptor complex p23; telomerase-binding protein p23; unactive progesterone receptor, 23 kD; prostaglandin E synthase 3 (cytosolic); Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23
other gene names :
PTGES3; PTGES3; P23; TEBP; cPGES; P23; TEBP; cPGES
uniprot entry name :
TEBP_HUMAN
sequence length :
160
sequence :
MQPASAKWYD RRDYVFIEFC VEDSKDVNVN FEKSKLTFSC LGGSDNFKHL NEIDLFHCID PNDSKHKRTD RSILCCLRKG ESGQSWPRLT KERAKLNWLS VDFNNWKDWE DDSDEDMSNF DRFSEMMNNM GGDEDVDLPE VDGADDDSQD SDDEKMPDLE
purity :
> 95% by SDS - PAGE
form :
Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol
concentration :
0.5 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human
other info2 :
Expression System: E Coli
products categories :
Heat Shock Proteins
products description :
Prostaglandin E synthase 3 (PTGES3), also known as P23 or TEBP (Telomerase binding protein p23), is a ubiquitously expressed protein that functions as a cochaperone and plays an important role in signal transduction. This protein is a molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Recombinant PTGES3 protein was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Hawkins GA., et al. (2009) J Allergy Clin Immunol. 123(6):1376-83.e7. Nuttinck F., et al. (2008) Reproduction. 135(5):593-603.
ncbi gi num :
23308579
ncbi acc num :
NP_006592
ncbi gb acc num :
NM_006601.6
ncbi mol weight :
18.6 kDa (160aa), confirmed by MALDI-TOF.
ncbi pathways :
AhR Pathway (755436); Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (685553); Arachidonic Acid Metabolism Pathway (366); Attenuation Phase Pathway (1127556); C20 Prostanoid Biosynthesis Pathway (545299); C20 Prostanoid Biosynthesis Pathway (908107); Cellular Response To Heat Stress Pathway (1127553); Cellular Responses To Stress Pathway (645258); HSF1 Activation Pathway (1127554)
uniprot summary :
TEBP: Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Belongs to the p23/wos2 family. Protein type: Transferase; EC 5.3.99.3; Nuclear receptor co-regulator; Isomerase; Chaperone. Chromosomal Location of Human Ortholog: 12q13.3 12. Cellular Component: nucleoplasm; chromosome, telomeric region; cytoplasm; telomerase holoenzyme complex; cytosol; nucleus. Molecular Function: telomerase activity; protein binding; unfolded protein binding; prostaglandin-E synthase activity. Biological Process: RNA-dependent DNA replication; cyclooxygenase pathway; arachidonic acid metabolic process; signal transduction; prostaglandin biosynthetic process; telomere maintenance
size1 :
0.1 mg
price1 :
375 USD
size2 :
0.5 mg
price2 :
925
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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