ACBP, 1-87aa, Human, His tag, E Coli | MyBioSource MBS203475 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

ACBP, 1-87aa, Human, His tag, E Coli

catalog :

MBS203475

quantity :

0.1 mg

price :

285 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS203475

products type :

Recombinant Protein

products full name :

ACBP, 1-87aa, Human, His tag, E Coli

products short name :

ACBP

products name syn :

ACBD1; CCK-RP; EP; DBI; Acyl-CoA-binding protein; Diazepam Binding Inhibitor Protein

other names :

acyl-CoA-binding protein isoform 3; Acyl-CoA-binding protein; acyl-CoA-binding protein; GABA receptor modulator; acyl coenzyme A binding protein; acyl-Coenzyme A binding domain containing 1; cholecystokinin-releasing peptide, trypsin-sensitive; diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein); diazepam-binding inhibitor; endozepine; diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein); Diazepam-binding inhibitor; DBI; Endozepine; EP

products gene name :

ACBP

other gene names :

DBI; DBI; EP; ACBP; ACBD1; CCK-RP; ACBP; DBI; EP

uniprot entry name :

ACBP_HUMAN

sequence length :

sequence :

MGSSHHHHHH SSGLVPRGSH MSQAEFEKAA EEVRHLKTKP SDEEMLFIYG HYKQATVGDI NTERPGMLDF TGKAKWDAWN ELKGTSKEDA MKAYINKVEE LKKKYGI

purity :

> 95% by SDS - PAGE

form :

Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.1M NaCl, 10% glycerol

concentration :

1 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human. Tag: His-tag

other info2 :

Expression System: E Coli

products categories :

Neuroscience

products description :

ACBP, also known as ACBD1, is a diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. Expression of ACBP is significantly induced during adipocyte differentiation. ACBP is a target for proliferator-activated receptor (PPAR)gamma, and is directly activated by PPARgamma/RXRalpha and PPARalpha/RXRalpha, but not by PPARdelta/RXRalpha. Recombinant human ACBP protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

products references :

Folli F., et al. (2010) PLoS One. 5(3):e9923. Manjithaya R., et al. (2010) J Cell Biol. 188(4):537-46.

ncbi gi num :

120433590

ncbi acc num :

NP_001073331

ncbi gb acc num :

NM_001079862.2

ncbi mol weight :

12.2 kDa (107aa), confirmed by MALDI-TOF

ncbi pathways :

PPAR Signaling Pathway (83042); PPAR Signaling Pathway (450); SREBP Signalling Pathway (219802)

ncbi summary :

This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

DBI: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. Belongs to the ACBP family. 6 isoforms of the human protein are produced by alternative promoter. Protein type: Lipid-binding. Chromosomal Location of Human Ortholog: 2q12-q21. Cellular Component: Golgi apparatus; mitochondrion; endoplasmic reticulum. Molecular Function: protein dimerization activity; benzodiazepine receptor binding; lipid binding. Biological Process: protein palmitoylation; triacylglycerol metabolic process; learning and/or memory; behavioral fear response; hair follicle development; transport; lateral ventricle development

size1 :

0.1 mg

price1 :

285 USD

size2 :

0.5 mg

price2 :

640

more info or order :

MyBioSource product webpage