protein

PPARG, 209-477aa, Human, His tag, E Coli

MBS203469

0.1 mg

310 USD

Recombinant Protein

PPARG, 209-477aa, Human, His tag, E Coli

PPARG

NR1C3; CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARgamma; Peroxisome proliferator-activated receptor gamma

peroxisome proliferator-activated receptor gamma isoform 1; Peroxisome proliferator-activated receptor gamma; peroxisome proliferator-activated receptor gamma; PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated nuclear receptor gamma variant 1; peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3

PPARG

PPARG; PPARG; GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma; NR1C3; PPAR-gamma

PPARG_HUMAN

477

MGSSHHHHHH SSGLVPRGSH MADLRALAKH LYDSYIKSFP LTKAKARAIL TGKTTDKSPF VIYDMNSLMM GEDKIKFKHI TPLQEQSKEV AIRIFQGCQF RSVEAVQEIT EYAKSIPGFV NLDLNDQVTL LKYGVHEIIY TMLASLMNKD GVLISEGQGF MTREFLKSLR KPFGDFMEPK FEFAVKFNAL ELDDSDLAIF IAVIILSGDR PGLLNVKPIE DIQDNLLQAL ELQLKLNHPE SSQLFAKLLQ KMTDLRQIVT EHVQLLQVIK KTETDMSLHP LLQEIYKDLY

> 95% by SDS - PAGE

Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.1M NaCl

1.0 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Transcription & Translation

PPARG, also known as Peroxisome proliferator-activated receptor gamma, is member of the nuclear hormone receptor subfamily of transcription factors. This protein regulates transcription of genes involved in Insulin action, adipocyte differentiation, lipid metabolism and inflammation. It is implicated in numerous diseases including obesity, diabetes, atherosclerosis and cancer. It also activators include prostanoids, fatty acids, thiazolidinediones and N-(2-benzoylphenyl) tyrosine analogues. PPARG may modulate macrophage functions such as proinflammatory activities, and stimulate oxidized low-density lipoprotein (x-LDL) uptake. Recombinant human PPARG protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Berger J. et al. (2002) Annu Rev Med. 53:409-35. Michalik L.,et al. (2006) Pharmacol Rev. 58(4):726-41.

116284373

NP_619725

NM_138711.3

33.0kDa (290aa) confirmed by MALDI-TOF

AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!Adipogenesis Pathway 198832!!Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway 137993!!Developmental Biology Pathway 477129!!Energy Metabolism Pathway 198907!!Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway 160977!!Gene Expression Pathway 105937!!Generic Transcription Pathway 105938!!Huntington's Disease Pathway 83100

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

0.1 mg

310 USD