Recombinant Tankyrase 2 (TNKS2) | MyBioSource MBS2034409 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Tankyrase 2 (TNKS2)

catalog :

MBS2034409

quantity :

0.01 mg

price :

130 USD

more info or order :

MyBioSource product webpage

image

image 1 :

image 2 :

product information

catalog number :

MBS2034409

products type :

Recombinant Protein

products full name :

Recombinant Tankyrase 2 (TNKS2)

products short name :

[Tankyrase 2]

products name syn :

[PARP5B; PARP5C; TANK2; TNKL; Tankyrase-like protein; ADP-ribosyltransferase diphtheria toxin-like 6; TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2]

other names :

[tankyrase 2; Tankyrase-2; tankyrase-2; tankyrase 2; ADP-ribosyltransferase diphtheria toxin-like 6; ARTD6; Poly [ADP-ribose] polymerase 5B; TNKS-2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; Tankyrase II; Tankyrase-like protein; Tankyrase-related protein]

products gene name :

[TNKS2]

other gene names :

[TNKS2; TNKS2; TNKL; ARTD6; TANK2; pART6; PARP5B; PARP5C; PARP-5b; PARP-5c; PARP5B; TANK2; TNKL; TANK2; ARTD6]

uniprot entry name :

TNKS2_HUMAN

host :

E. coli

reactivity :

Human

purity :

>92%

form :

Reconstitute in 100mM NaHCO 3 , 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

concentration :

Original Concentration: 200µg/mL

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Positive Control, Immunogen, SDS-PAGE, WB. (May be suitable for use in other assays to be determined by the end user.)

image1 heading :

Sequence Information

image2 heading :

SDS-Page

other info1 :

Source: Prokaryotic expression. Residues: Ser959~Gly1166. Tags: N-terminal His-Tag. Tissue Specificity: Placenta, Skeletal Muscle, Liver, Brain. Subcellular Location: Cytoplasm. Golgi Apparatus Membrane; Peripheral Membrane Protein. Nucleus. Chromosome. Traits: Freeze-dried powder. Predicted isoelectric point: 8.5. Predicted Molecular Mass: 27.4kDa. Accurate Molecular Mass: 29kDa as determined by SDS-PAGE reducing conditions. Usage: 100mM NaHCO 3 , 500mM NaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300

ncbi gi num :

13161042

ncbi acc num :

AAK13463.1

ncbi pathways :

Degradation Of AXIN Pathway (1269606); Disease Pathway (1268854); Diseases Of Signal Transduction Pathway (1268855); Signal Transduction Pathway (1269379); Signaling By WNT In Cancer Pathway (1268906); Signaling By Wnt Pathway (1269594); TCF Dependent Signaling In Response To WNT Pathway (1269599); XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway (1268925)

uniprot summary :

TNKS2: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP- ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Protein type: Transferase; Nuclear envelope; EC 2.4.2.30. Chromosomal Location of Human Ortholog: 10q23.3. Cellular Component: cytoplasm; cytosol; Golgi membrane; nuclear chromosome, telomeric region; nuclear envelope; nucleus; pericentriolar material; perinuclear region of cytoplasm. Molecular Function: enzyme binding; metal ion binding; NAD+ ADP-ribosyltransferase activity; protein binding. Biological Process: multicellular organism growth; positive regulation of telomere maintenance via telomerase; protein amino acid ADP-ribosylation; protein polyubiquitination; regulation of multicellular organism growth; Wnt receptor signaling pathway

size1 :

0.01 mg

price1 :

130 USD

size2 :

0.05 mg

price2 :

225

size3 :

0.1 mg

price3 :

340

size4 :

0.2 mg

price4 :

415

size5 :

0.5 mg

price5 :

800

size6 :

1 mg

price6 :

1180

more info or order :

MyBioSource product webpage