catalog number :
MBS2034259
products type :
Recombinant Protein
products full name :
Recombinant Neuro Oncological Ventral Antigen 1 (NOVA1)
products short name :
[Neuro Oncological Ventral Antigen 1]
products name syn :
[Onconeural ventral antigen 1; Paraneoplastic Ri antigen; Ventral neuron-specific protein 1; RNA-binding protein Nova-1]
other names :
[Neuro-oncological ventral antigen 1; RNA-binding protein Nova-1; RNA-binding protein Nova-1; neuro-oncological ventral antigen 1; Neuro-oncological ventral antigen 1; Onconeural ventral antigen 1; Paraneoplastic Ri antigen; Ventral neuron-specific protein 1]
products gene name :
[NOVA1]
other gene names :
[NOVA1; NOVA1; Nova-1]
uniprot entry name :
NOVA1_HUMAN
form :
20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300.
storage stability :
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
SDS-PAGE, WB, ELISA, IP, CoIP, Purification, Amine Reactive Labeling. (May be suitable for use in other assays to be determined by the end user.)
image1 heading :
Sequence Information
image2 heading :
SDS-Page
other info1 :
Source: Prokaryotic expression. Residues: Ala295~Gly510. Tags: N-terminal His-Tag. Tissue Specificity: Brain. Subcellular Location: Nucleus.
Traits: Freeze-dried powder.
other info2 :
Predicted isoelectric point: 8.9. Predicted Molecular Mass: 24.8kDa. Accurate Molecular Mass: 25kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
ncbi acc num :
AAH75038.1
ncbi summary :
This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
uniprot summary :
NOVA1: May regulate RNA splicing or metabolism in a specific subset of developing neurons. 4 isoforms of the human protein are produced by alternative splicing. Protein type: RNA splicing; RNA-binding. Chromosomal Location of Human Ortholog: 14q. Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleus. Molecular Function: mRNA binding; RNA binding. Biological Process: locomotory behavior; nuclear mRNA splicing, via spliceosome; regulation of mRNA processing; RNA processing; RNA splicing; spinal cord development; synaptic transmission