protein

MAX, 1-160aa, Human, His tag, E Coli

MBS203404

0.1 mg

285 USD

Recombinant Protein

MAX, 1-160aa, Human, His tag, E Coli

MAX

bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8; MYC associated factor X Helix loop helix zipper protein; MAX protein; MGC10775; MGC11225; MGC18164; MGC34679; MGC36767; Myc associated factor X; Myc binding novel HLH/LZ protein; Orf 1; Orf1; Protein max.

protein max isoform a; Protein max; protein max; class D basic helix-loop-helix protein 4; MYC associated factor X; Class D basic helix-loop-helix protein 4; bHLHd4; Myc-associated factor X

MAX

MAX; MAX; bHLHd4; BHLHD4; bHLHd4

MAX_HUMAN

160

MSDNDDIEVE SDEEQPRFQS AADKRAHHNA LERKRRDHIK DSFHSLRDSV PSLQGEKASR AQILDKATEY IQYMRRKNHT HQQDIDDLKR QNALLEQQVR ALEKARSSAQ LQTNYPSSDN SLYTNAKGST ISAFDGGSDS SSESEPEEPQ SRKKLRMEAS LEHHHHHH

> 90% by SDS - PAGE

Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol

0.5 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Transcription & Translation

MAX is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. In contrast to Myc, which is highly regulated during progression through the cell cycle, Max is highly stable and is much more abundant than Myc. Recombinant human MAX protein, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Burbano HA., et al. (2010) Science. 328(5979):723-5.

21704261

NP_002373

NM_002382.4

19.3 kDa (168aa), confirmed by MALDI-TOF

C-MYC Pathway 169344!!Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765!!Cyclin A:Cdk2-associated Events At S Phase Entry Pathway 105783!!Cyclin E Associated Events During G1/S Transition Pathway 105770!!G1/S Transition Pathway 105769!!Integrated Breast Cancer Pathway 219801!!MAPK Signaling Pathway 198779!!MAPK Signaling Pathway 83048!!MAPK Signaling Pathway 456

The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

0.1 mg

285 USD