protein

RuNX3, 53-186aa, Human, His tag, E Coli

MBS203402

0.05 mg

310 USD

Recombinant Protein

RuNX3, 53-186aa, Human, His tag, E Coli

RuNX3

AML2; CBFA3; PEBP2aC; Runt-related transcription factor 3 Acute myeloid leukemia 2 protein; Acute myeloid leukemia gene 2; AML 2; CBF alpha 3; CBFA 3; Core binding factor alpha 3 subunit; core binding factor; Core binding factor runt domain alpha subunit 3; Core binding factor subunit alpha 3.M574; core-binding factor; FLJ34510; MGC16070; Oncogene AML 2; PEA2 alpha C; PEBP2 alpha C; Pebp2a3; Polyomavirus enhancer binding protein 2 alpha C subunit; runt domain alpha subunit 3; runt related transcription factor 3; RuNX 3; SL3 3 enhancer factor 1 alpha C subunit; SL3/AKV core binding factor alpha C subunit; Transcription factor AML2.

runt-related transcription factor 3 isoform 2; Runt-related transcription factor 3; runt-related transcription factor 3; CBF-alpha-3; PEA2 alpha C; PEA2-alpha C; PEBP2 alpha C; PEBP2-alpha C; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; acute myeloid leukemia 2 protein; acute myeloid leukemia gene 2; core-binding factor subunit alpha-3; core-binding factor, runt domain, alpha subunit 3; oncogene AML-2; polyomavirus enhancer-binding protein 2 alpha C subunit; transcription factor AML2; runt-related transcription factor 3; Acute myeloid leukemia 2 protein; Core-binding factor subunit alpha-3; CBF-alpha-3; Oncogene AML-2; Polyomavirus enhancer-binding protein 2 alpha C subunit; PEA2-alpha C; PEBP2-alpha C; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit

RuNX3

RUNX3; RUNX3; AML2; CBFA3; PEBP2aC; AML2; CBFA3; PEBP2A3; CBF-alpha-3; PEA2-alpha C; PEBP2-alpha C

RUNX3_HUMAN

415

MGSSHHHHHH SSGLVPRGSH MRSMVDVLAD HAGELVRTDS PNFLCSVLPS HWRCNKTLPV AFKVVALGDV PDGTVVTVMA GNDENYSAEL RNASAVMKNQ VARFNDLRFV GRSGRGKSFT LTITVFTNPT QVATYHRAIK VTVDGPREPR RHRQK

> 95% by SDS - PAGE

Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol 0.1M NaCl,1mM DTT

0.5 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Transcription & Translation

RuNX3, also known as runt-related transcription factor 3, belongs to the RuNX family that regulate the expression of genes involved in cellular differentiation and cell cycle progression. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It is a strong candidate as a gastric cancer tumor suppressor. Recombinant human RuNX3, fused to His-tag at N-terminus, protein was expressed in E.coli and purified by using conventional chromatography techniques

Vogiatzi P. et al. (2006) Cancer Biol Ther. 5(4):371-4. Li QL,et al. (2002)Cell. 109(1):113-24.

4757918

NP_004341

NM_004350.2

17.1 kDa (155aa) confirmed by MALDI-TOF

Endochondral Ossification Pathway 198812!!SIDS Susceptibility Pathways 198901!!TGF Beta Signaling Pathway 198810

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

0.05 mg

310 USD